Anthony Laboratory: Robert Anthony, PhD

Overview

Antibodies are the preeminent effector proteins of the immune system. The bimodal activity of antibodies allows simultaneous recognition of antigen (by the antigen-binding fragment, Fab) with high affinity, and recruitment and activation of leukocytes through interactions between the constant, crystallizable fragment (Fc) and Fc receptors (FcRs) expressed by innate immune cells. Studies have demonstrated that antibody glycosylation is an important regulator of Fc-FcR interactions. The Anthony Laboratory at Massachusetts General Hospital is particularly interested in the role and regulation of IgE and IgG glycosylation in health and disease.

Research Projects

• The Role and Regulation of IgE Glycosylation in Allergy
• The Role and Regulation of IgG Glycosylation in Homeostasis and Disease

Meet the Team

Robert Anthony, PhD Principal Investigator, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital Associate Professor of Medicine, Harvard Medical School

Group Members

Junior Faculty:
Michelle Conroy, MD
Kai-Ting Chuang Shade, PhD

Postdoctoral Fellows:
Tina Motazedi, MD
Ravi Vattepu, PhD

Research Associate:
Jose Pagan, MD

Lab Manager:
Alex Trachtenberg

Research Technicians:
Daniel Huynh
Sunny Sneed

Publications

Click here to view a list of publications from this investigator.