The Mempel Laboratory at Massachusetts General Hospital studies cell migration and communication in the adaptive immune system through in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.
T lymphocytes are part of the adaptive immune system. They are powerful players in the defense against infection and can be effective against tumors, but they are also involved in autoimmune responses, leading to diseases such as diabetes, arthritis or multiple sclerosis.
T cell responses arise from clonal expansion of a small number of naïve precursors through antigenic priming by dendritic cells in secondary lymphoid organs, such as lymph nodes and the spleen. Once these naïve T cells have differentiated to effector T cells, they migrate to the blood, from where they are recruited to peripheral tissues to combat disease.
To prevent attacks on healthy tissues, the execution of T cell effector functions is tightly linked to the recognition of cognate antigen. In addition, immune responses are regulated through diverse inhibitory and stimulatory signals that T cells encounter in peripheral tissues.
The Mempel's Laboratory at Massachusetts General Hospital is seeking to understand how the function of T cells is regulated through their interaction with other cells, structural tissue components and soluble mediators that they encounter in tissues. Their main approach to this end is direct dynamic in vivo visualization of immune processes at cellular and subcellular resolution in living mice, using multiphoton intravital microscopy.
Mechanisms of Cytotoxic T Cell-mediated Tumor Rejection
Local Regulation of T Effector Cell Function by T Regulatory Cells
Interplay of T Regulatory Cells and Tumor-associated Myeloid Cells
Early Events of Viral Spread in a Humanized Mouse Model of HIV Infection
Role of IP-10 Chemokine in T Cell Migration (with Luster Lab)
Function of Microglia in Alzheimer’s Disease (with El Khoury Lab)
Self-renewal of Cancer Stem Cells (with Langenau Lab)
Thorsten R. Mempel, MD, PhD Principal Investigator, Center for Immunoloy and Inflammatory Diseases, Massachusetts General Hospital Associate Director, CIID, Massachusetts General Hospital Professor of Medicine, Harvard Medical School
Research Fellows: Lukas Altenburger, PhD Taylor Chrisikos, PhD Mohsen Maleh Mir, PhD Kazuhiro Taguchi, MD, PhD