About Jatin Vyas, MD, PhD

As a physician-scientist interested in immunology and infectious diseases, I focus on basic investigations of host-pathogen interactions.  I have a long-standing interest in immune responses to infections. My laboratory focuses on the innate immune responses to clinically relevant fungal pathogens. We employ both cell biological and biochemical tools to understand the molecular mechanisms that govern host immunity to these microorganisms. Using mouse models with defined defects in innate immunity, we have described key mechanisms that orchestrate this immune response to fungal infections.

I also serve as the tenth Program Director of the  Massachusetts General Hospital Department of Medicine Residency Program. I  currently supervise 207 interns and residents. As an NIH-funded investigator with interests in basic science, I provide a unique perspective to the medical housestaff. Outstanding clinical care is fueled by basic discovery and our greatest opportunities to improve patient care comes from high-quality research.

Departments, Centers, & Programs:



Infectious Disease Associates
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-643-6444
Phone: 617-643-8949
Fax: 617-643-6443

Medical Education

  • MD, Baylor College of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Brigham and Women's Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Internal Medicine, American Board of Internal Medicine
  • Infectious Disease, American Board of Internal Medicine
  • Infectious Disease, American Board of Internal Medicine

Accepted Insurance Plans

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View my most recent research

The central theme in my laboratory is to understand the rules that govern the immune system against pathogenic microorganisms. To do so, we utilize the model system of invasive fungal infections to determine the molecular basis of recognition of pathogenic fungi by immune cells to effect host defense. We have demonstrated that phagocytosis (or engulfment of pathogenic fungi) by immune cells leads to activation of key signaling pathways that influence both the cell response and antigen processing and presentation. To conduct these studies, we have employed advanced microscopy to visualize dynamic subcellular changes upon phagocytosis by macrophages and dendritic cells. We have developed novel tools to dissect this immune response including the development of synthetic fungal-like particles, which display highly purified carbohydrates of fungal origin that trigger inflammatory responses in innate immune cells. My collection of work has led to novel insights into the host-fungi interaction with opportunities to develop novel strategies to augment the host immune response.