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About the Lab
The research in the Medoff Laboratory is dedicated to understanding the molecular basis of immune-mediated lung injury. Specifically, we seek to delineate the mechanisms of lung inflammation as it relates to T cell-mediated lung disorders such as asthma, lung transplant rejection and respiratory viral infections. The laboratory utilizes cutting-edge molecular biology techniques, genetic manipulation of mice, animal modeling of lung disease, integrative genomics and translational studies in humans to understand these disease processes.
The laboratory is affiliated with the Division of Pulmonary and Critical Care Medicine in the Department of Medicine at Mass General, as well as the Center for Immunology and Inflammatory Diseases, and the Division of Rheumatology, Allergy and Immunology. We have collaborations with Mass General laboratories in the Gastroenterology Unit, the Diabetes Unit, the Center for Computational and Integrative Biology, the Department of Molecular Biology and the Department of Anesthesia, Critical Care and Pain Medicine.
T cells in asthma.
- Role of CARMA1 in T cell-mediated allergic airway inflammation.
- Role of CARMA3 in innate immune-mediated activation of adaptive immunity in allergic airway inflammation.
- Relationship between T cell phenotype and airway hyperreactivity following segmental allergen challenge.
T cell mediated lung transplant rejection.
- Role of CARMA1 in lung transplant rejection.
- Role of TIM3 in lung transplant rejection.
T cell mediated lung injury following influenza infection.
- Role of CARMA1 in the development of pneumonitis following influenza infection.
- Role of TIM3 in the development of pneumonitis following influenza infection.
Effects of T cell-mediated lung injury on the pulmonary vasculature - relationship to pulmonary arterial hypertension.
- Medoff BD, Wain JC, Seung E, Jackobek R, Means TK, Ginns LC, Farber JM, Luster AD. CXCR3 and its Ligands in a Murine Model of Obliterative Bronchiolitis: Regulation and Function. J Immunol. 2006; 176(11): 7087-7095. PMID: 16709871
- Medoff BD, Seed B, Jackobek R, Zora, J, Yany Y, Luster AD, Xavier, R. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. J Immunol. 2006; 176(12): 7272-7. PMID: 16751370
- Campanella GSV, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD. Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity. J Immunol 2006 177: 6991-6998. PMID: 17082614
- Thomas SY, Banerji A, Medoff BD, Lilly CM, Luster AD. Multiple chemokine receptors regulate antigen-induced T cell homing to the human asthmatic airway. J Immunol 2007; 179: 1901-1912.PMID: 17641057
- Medoff BD, Thomas SY, Luster AD. T cell trafficking in allergic asthma: The ins and outs. Annual Rev. Immunol. 2008, 26: 205-32. PMID: 18304002
- Campanella GS, Medoff BD, Manice LA, Colvin RA, Luster AD. Development of a novel chemokine-mediated in vivo T cell recruitment assay. J Immunol Methods. 2008; 331:127-39. PMID: 18206159
- Fadel SA, Bromley SK, Medoff BD, Luster AD. CXCR3-deficiency Protects Influenza-infected CCR5-deficient Mice from Mortality. Eur J Immunol. 2008. 38(12):3376-87. PMID: 19039768
- Afshar R, Medoff BD, Luster AD. Allergic Asthma: A Tale of Many T cells. Clin Exp Allergy. 2008. 38(12):1847-57. Review. PMID: 19037961
- Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20321-6. Epub 2008 Dec 10. PMID: 19073936
- Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ. CARMA3 Mediates Lysophosphatidic Acid Stimulated Cytokine Secretion by Bronchial Epithelial Cells. Am J Respir Cell Mol Biol. Am J Respir Cell Mol Biol. 2009 40(3):286-94. PMID: 18757306
- Mikhak Z, Fukui M, Farsidjani A, Medoff BD, Tager AM, Luster AD. Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.J Allergy Clin Immunol. 2009 Jan;123(1):67-73.e3. Epub 2008 Dec 4. PMID: 19062085
- Medoff BD, Sandall BP, Landry A, Nagahama K, Mizoguchi A, Luster AD, Xavier RJ. Differential requirement for CARMA1 in agonist-selected T-cell development.. Eur J Immunol. 2009 Jan;39(1):78-84. PMID: 19130560
- Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD. CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.J Immunol. 2009 Jan 1;182(1):623-35. PMID: 19109196
- Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P, Luster AD. Adiponectin-deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling.Am J Respir Cell Mol Biol. 2009 41(4):397-406 PMID: 19168697.
- Ramadas RA, Ewart SL, Medoff BD, LeVine AM. IL1F9 Stimulates chemokine production and neutrophil influx in mouse lungs. Am J Respir Cell Mol Biol. 2010. In Press
Research Group Members
Josalyn Cho, MD
Benjamin Causton, Ph.D
Jason Griffith, MD, Ph.D
Anna Labowsky, MD
Marly Roche, Ph.D
Tiiu Saarne, Ph.D
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