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Research Interests

Krishna Reddy, MD, MS, studies tobacco, HIV and tuberculosis, both individually and in combination. Along with colleagues in the Medical Practice Evaluation Center at Massachusetts General Hospital, he applies methods of simulation modeling, epidemiology and cost-effectiveness analysis to study clinical and economic outcomes in the U.S. and other countries. The goal of his research program is to provide evidence- and model-based approaches to clinical decision-making, trial design and public health policy.

Awards and Recognitions

Dr. Reddy is the principal investigator of research awards from the National Institutes of Health. His work has been reported by NBC News, Reuters and WBUR/National Public Radio. Dr. Reddy has been a consultant to the World Health Organization (WHO), and his work has been cited in clinical guidelines of the WHO and the U.S. Department of Health and Human Services.

More information can be found on Dr. Reddy’s Harvard Catalyst Profile.

Current Projects

  • Clinical and economic outcomes of smoking and smoking cessation among people with HIV in the U.S. and in South Africa
  • Model-based projections of uptake and outcomes of e-cigarettes
  • Cost-effectiveness analysis of tuberculosis diagnostic and treatment strategies in resource-limited settings
  • Use of value-of-information analysis and other modeling methods to inform clinical trial development in HIV and tuberculosis
  • Model-based studies of care strategies in pulmonary and critical care medicine

Selected Publications

Full list of publications from Dr. Reddy >

Reddy KP, Shebl FM, Foote JHA, Harling G, Scott JA, Panella C, Fitzmaurice KP, Flanagan C, Hyle EP, Neilan AM, Mohareb AM, Bekker LG, Lessells RJ, Ciaranello AL, Wood R, Losina E, Freedberg KA, Kazemian P, Siedner MJ. Cost-effectiveness of public health strategies for COVID-19 epidemic control in South Africa: a microsimulation modelling study. Lancet Glob Health. 2021 Feb;9(2):e120-e129. DOI: 10.1016/S2214-109X(20)30452-6.

Reddy KP, Denkinger CM, Broger T, McCann NC, Gupta-Wright A, Kerkhoff AD, Pei PP, Shebl FM, Fielding KL, Nicol MP, Horsburgh CR, Meintjes G, Freedberg KA, Wood R, Walensky RP. Cost-effectiveness of a novel lipoarabinomannan test for tuberculosis in patients with HIV. Clin Infect Dis. 2020 Nov 17:ciaa1698. DOI: 10.1093/cid/ciaa1698.

Reddy YNV, Walensky RP, Mendu ML, Green N, Reddy KP. Estimating shortages in capacity to deliver continuous kidney replacement therapy during the COVID-19 pandemic in the United States. Am J Kidney Dis. 2020 Nov;76(5):696-709.e1. DOI: 10.1053/j.ajkd.2020.07.005.

Reddy KP, Bulteel AJB, Levy DE, Torola P, Hyle EP, Hou T, Osher B, Yu L, Shebl FM, Paltiel AD, Freedberg KA, Weinstein MC, Rigotti NA, Walensky RP. Novel microsimulation model of tobacco use behaviours and outcomes: calibration and validation in a US population. BMJ Open. 2020 May 12;10(5):e032579. DOI: 10.1136/bmjopen-2019-032579.

Reddy KP, Horsburgh CR, Wood R, Fields NF, Girouard MP, Costantini S, Hou T, Freedberg KA, Walensky RP. Shortened tuberculosis treatment for people with HIV in South Africa: a model-based evaluation and cost-effectiveness analysis. Ann Am Thorac Soc. 2020 Feb;17(2):202-211. DOI: 10.1513/AnnalsATS.201905-418OC.

Lee DJ, Kumarasamy N, Resch SC, Sivaramakrishnan GN, Mayer KH, Tripathy S, Paltiel AD, Freedberg KA, Reddy KP. Rapid, point-of-care diagnosis of tuberculosis with novel Truenat assay: cost-effectiveness analysis for India’s public sector. PLoS One. 2019 Jul 2;14(7):e0218890. DOI: 10.1371/journal.pone.0218890.

Reddy KP, Gupta-Wright A, Fielding KL, Costantini S, Zheng A, Corbett EL, Yu L, van Oosterhout JJ, Resch SC, Wilson DP, Horsburgh CR, Wood R, Alufandika-Moyo M, Peters JA, Freedberg KA, Lawn SD, Walensky RP. Cost-effectiveness of urine-based tuberculosis screening in hospitalised patients with HIV in Africa: A microsimulation modelling study. Lancet Glob Health. 2019 Feb;7:e200-e208. DOI: 10.1016/S2214-109X(18)30436-4.

Reddy KP, Kong CY, Hyle EP, Baggett TP, Huang M, Parker RA, Paltiel AD, Losina E, Weinstein MC, Freedberg KA, Walensky RP. Lung cancer mortality associated with smoking and smoking cessation among people living with HIV in the United States. JAMA Intern Med. 2017 Nov 1;177(11):1613-1621. DOI: 10.1001/jamainternmed.2017.4349.

Reddy KP, Parker RA, Losina E, Baggett TP, Paltiel AD, Rigotti NA, Weinstein MC, Freedberg KA, Walensky RP. Impact of cigarette smoking and smoking cessation on life expectancy among people with HIV: a US-based modeling study. J Infect Dis. 2016 Dec 1;214(11):1672-1681. DOI: 10.1093/infdis/jiw430.