The Rehm Laboratory at Massachusetts General Hospital has a mission to support the use of genomics in the practice of medicine. The lab is focused on community-centered projects that promote collaboration, data sharing and open science. At Mass General, Rehm is helping roll out genomics across the healthcare system through system-wide efforts to standardize genetic and genomic practices across providers and support their appropriate use in caring for patients. At the Broad Institute, Rehm oversees efforts in rare disease gene discovery and building clinical genomic knowledge resources to support the use of genetics and genomics in research and medicine.