Research Investigator Profile

Merit Cudkowicz, MD
Merit Ester Cudkowicz, MD
  • Chief, Neurology Service
  • Director, Amyotrophic Lateral Sclerosis Clinic
  • Co-Director, Neuromuscular Division

Research Description

My research and clinical activities are dedicated to the study and treatment of patients with neurodegenerative disorders, in particular amyotrophic lateral sclerosis (ALS) and Huntington’s Disease (HD). My lab conducts experimental therapeutic trials of novel agents in a mouse transgenic ALS model; we have tested over 25 different therapies.

I am director of the MGH Amyotrophic Lateral Sclerosis (ALS) clinic and the Neurological Clinical Research Institute (NCRI) at MGH and Partners HealthCare System.


Research interests Amyotrophic lateral sclerosis, experimental therapeutics, Huntington's Disease, clinical trial design, biomarker development and epidemiology
Research techniques Clinical trials design and management
Diseases studied Amyotrophic lateral sclerosis (ALS) and Huntington's disease
Selected publications
  1. Qureshi M, Schoenfeld D, Paliwal Y, Shui A, Cudkowicz ME. The natural history of ALS is changing; improved survival. Amyotroph Lateral Scler 2009: 10(5-6);324-331.
  2. Castrillo C, Grasso D, Simpson E, Shefner J, Cudkowicz ME. Clinical significance of change in ALSFRS-R. Amyotroph Lateral Scler 2009: Epub Jul 26:1-3.
  3. Kaufmann P, Thompson JLP, Levy G, et al for the QALS Study Group. Phase II trial of CoQ10 for ALS finds insufficient evidence to justify Phase III. Annals of Neurology 2009; 2:235-44.
  4. Qureshi M, Bedlack RS, Cudkowicz ME.  Lyme disease serology in amyotrophic lateral sclerosis. Muscle and Nerve 2009: 40(4):626-630.
  5. Harel NY, Cudkowicz ME, Brown RH, Strittmatter SM. Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients. Biomarkers 2009;1-4, iFirst.
NCBI PubMed link NCBI PubMed Publications
Collaborators Nazem Atassi, MD
William David, MD, PhD
Anne Marie Wills, MD, MPH
E-mail address
Lab mailing address

Neurological Clinical Research Institute
13th Street Building 149 Room 2274
Charlestown, MA 02129

Clinical interests ALS, Parkinson's disease
Clinical address Neurology, Suite 835
Massachusetts General Hospital
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Amyotrophic Lateral Sclerosis (ALS) Multidisciplinary Clinic



Updated 05/02/2017

Back to Top