Research Investigator Profile

Jeremy Schmahmann, MD

Jeremy D. Schmahmann, MD

  • Professor of Neurology,
    Harvard Medical School
  • Director, Ataxia Unit,
    Massachusetts General Hospital



Research Description

I am a neurologist with an active clinical practice, engaged in neuroanatomical as well as translational research, and committed to teaching at all levels. I am particularly interested in understanding the substrates of cognition and emotion, including the role of the cerebellum and cerebral white matter fiber pathways. In my teaching I attempt to share the excitement regarding these evolving concepts. My clinical practice flows from these interests and is devoted to patients with cerebellar disorders and those presenting with impairments of cognition. Read More.

Research interests Clinical and anatomical research focuses on structure-function correlations in behavioral neurology; and in particular, the role of the cerebellum in cognition and emotion.
Research techniques Clinical observations in patients; Functional Magnetic Resonance Imaging (fMRI); Tractography with Diffusion Spectrum Imaging (DSI); Neuroanatomical tract tracing studies in animal models
Diseases studied Ataxia Unti: Diseases of the cerebellum: sporadic and hereditary ataxias; developmental and neurodegenerative cerebellar disorders. Cognitive Behavioral Neurology Unit: Dementia and related conditions.
Selected publications
  1. Schmahmann JD and Sherman JC. The cerebellar cognitive affective syndrome. Brain 1998; 121: 561-579.
  2. Makris N, Schlerf JE, Hodge SM, Haselgrove C, Albaugh MD, Seidman LJ, Rauch SL, Harris GJ, Biederman J, Caviness VS, Kennedy DN, Schmahmann JD.  MRI-based surface assisted parcellation of human cerebellar cortex: An anatomically specified method with estimate of reliability. Neuroimage 2005: 25: 1146-1160.5.  
  3. Schmahmann JD, Pandya DN, Wang R, Dai G, D’Arceuil HE, de Crespigny AJ, Wedeen VJ. Association fiber pathways of the brain: Parallel observations from diffusion spectrum imaging and autoradiography. Brain. 2007; 130: 630-53.
  4. Schmahmann JD, Pandya DN. Disconnection syndromes of basal ganglia, thalamus and cerebrocerebellar systems. Cortex. 2008; 44: 1037-66.
  5. Stoodley CJ, Schmahmann JD. Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies. NeuroImage, 2008.
NCBI PubMed link NCBI PubMed Publications
E-mail address
Lab mailing address

Massachusetts General Hospital
Suite 340
175 Cambridge Street
Boston, MA 02114

Lab website Laboratory for Neuroanatomy and Cerebellar Neurobiology
Clinical interests

Ataxia - disease of the cerebellum, cerebellar dysfunction.

Cognitive Behavioral Neurology - Behavioral manifestations of focal cerebral lesions, and neurologic - psychiatric overlap syndromes

Geriatric Neurobehavior - Elderly patients with disorders of memory, personality, comportment and intellect

Clinical mailing address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Ataxia Unit at Massachusetts General Hospital

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