Research Investigator Profile

Anne-Marie Wills

Anne-Marie Wills, MD, MPH

  • Assistant Professor of Neurology,
    Harvard Medical School
  • Associate in Neurology,
    Massachusetts General Hospital



Research Description

Dr. Wills is interested in environmental risk factors and determinants of neurodegenerative disease progression including nutrition, caffeine and pesticides.

She is currently the Principal Investigator of a multi-center clinical trial funded by the Muscular Dystrophy Association to study the effects of increasing the caloric intake of ALS (Lou Gehrig's Disease) patients. Studies from both human and animal research data have shown an increase in longevity where mild obesity is present.

Dr. Wills is the Mass General Investigator on several Parkinson's Disease clinical trials testing therapeutic interventions in PD, and an investigator with the Parkinson's Study Group, and the Net-PD exploratory trials in Parkinson's Disease.

Research interests Environmental risk factors, determinants of neurodegenerative disease progression
Research techniques Human and animal research studies
Diseases studied Amyotrophic Lateral Sclerosis, Parkinson's disease
Selected publications
  1. Paganoni S; Deng J; Jaffa M; Cudkowicz ME; Wills AM. Body Mass Index, not dyslipidemia, is an independent predictor of survival in ALS, Muscle and Nerve, 2011 Jul;44(1):20-4
  2. Haramati S. et al. miRNA malfunction causes spinal motor neuron disease. PNAS, 2010 Jul 20;107(29):13111-6.
  3. Wills AM, et al. A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology. 2009;73(1):16-24.
  4. Landers JE et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009;106(22):9004-9.
  5. Wills A-M, Landers JE, Zhang H, Richter RJ, Caraganis A, Cudkowicz ME, Furlong CE, Brown RH Jr1. Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS. Neurology. 2008;70(12):929-34.
NCBI PubMed link NCBI PubMed publications
Collaborators Co-authors (on Harvard Catalyst)
Lab mailing address

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02110

Clinical interests Movement disorders, neurodegenerative disease, motor neuron disease
Clinical address Massachusetts General Hospital
Neurology, Suite 835
Wang Ambulatory Care Center
55 Fruit Street
Boston, MA 02114 USA
Clinical website address Amyotrophic Lateral Sclerosis Multidisciplinary Clinic
Movement Disorders Unit



Updated 04/25/2012

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