Key Takeaways

  • Administering the sedatives propofol or dexmedetomidine when circulation is restored following cardiac arrest improved survival and brain function in mice
  • The findings suggest that sedation of patients recovering from cardiac arrest in the intensive care unit may have protective effects on the brain

BOSTON – New research conducted in mice indicates that administering sedatives when circulation is restored following cardiac arrest may help to improve survival and brain function.

The study, which was led by investigators at Massachusetts General Hospital (MGH) and is published in Anesthesiology, suggests that this strategy should be tested in patients to help improve their outcomes after cardiac arrest.

Following cardiac arrest, mice received intravenous infusion of the sedatives propofol or dexmedetomidine, or saline (as a control), starting when the animals’ circulation spontaneously returned or at 60 minutes after return of spontaneous circulation.

Body temperature was lowered during sedation, and the brain’s blood flow and electrical activity were monitored.

Sedation with propofol or dexmedetomidine starting at return of spontaneous circulation improved survival compared with saline control (81%, 88%, and 25% survival in the respective groups of mice).

Sedation starting at return of spontaneous circulation also accelerated the recovery of brain activity (as assessed through electroencephalogram, or EEG, tests) and lessened blood flow abnormalities in the brain called cerebral hyperemia. Delayed sedation (60 minutes after return of spontaneous circulation) did not have these beneficial effects.

“Sedation in comatose post-arrest mice stimulated the recovery of slow wave EEG activity in the brain while post-arrest comatose mice that received no sedation remained with very little EEG activity for many hours. Faster recovery of slow wave EEG activity with sedation was associated with better neurological outcomes and survival after cardiac arrest,” says senior author Fumito Ichinose, MD, PhD, an attending physician in the Department of Anaesthesia, Critical Care and Pain Medicine at MGH and the William Thomas Green Morton Professor of Anesthesia at Harvard Medical School.

“Our results suggest that sedation of patients recovering from cardiac arrest in the intensive care unit may protect the brain.”

Additional co-authors include Takamitsu Ikeda, MD, PhD, Edilberto Amorim, MD, Yusuke Miyazaki, MD, PhD, Risako Kato, PhD, Eizo Marutani, MD, Michael G Silverman, MD, MPH, Rajeev Malhotra, MD, MS, and Ken Solt, MD.

This work was supported by a grant from the ZOLL Foundation and funds from the Department of Anesthesia, Critical Care and Pain Medicine, MGH.

Paper cited:

Ikeda, T., Amorim, E., Miyazaki, Y., Kato, R., Marutani, E., Silverman, M. G., Malhotra, R., Solt, K., & Ichinose, F. (2022). Post-cardiac Arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest. Anesthesiology, 10.1097/ALN.0000000000004390. Advance online publication.

About the Massachusetts General Hospital

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In July 2022, Mass General was named #8 in the U.S. News & World Report list of "America’s Best Hospitals." MGH is a founding member of the Mass General Brigham healthcare system.