Research Fellow Position in the Wang Lab

Current research in Wang Lab at the Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, mainly focuses on gynecological cancers, with an emphasis on ovarian high-grade serous carcinoma (HGSOC) and cervical squamous cell carcinoma (CSCC). The Research Fellow will be initially trained in the research laboratory and is expected to work independently after training to accomplish the proposed HGSOC/CSCC research projects under the supervision of Dr. Cheng Wang (Principal Investigator). The applicant is also responsible for documenting, analyzing and reporting the results derived from cellular models, mouse models and/or patient samples.

Job Description

The Research Fellow will receive training in cancer biology, ovarian/cervical cancer etiology, gynecological cancer cellular and mouse models, as well as many other laboratory research tools for studying ovarian/cervical cancer prevention and early detection. After initial training, the Research Fellow is expected to independently design and perform experiments to accomplish the proposed translational biomedical research project. The incumbent will study and collect basic research data related to assigned projects, perform statistical analysis of the generated results, prepare graphs, figures for publication and oral or poster presentations.

The Research Fellow is expected to maintain multiple breeding colonies of transgenic mice that are associated with his project. The candidate will routinely perform genotyping, small surgery in experimental animals, collect and process tissue samples from transgenic mice for histological, pathological and biochemical analyses.

The Research Fellow should perform independent literature searches to broaden knowledge in women’s cancers. S/he is expected to independently modify techniques as necessary to meet experimental needs under the direction of the Principal Investigator.

The incumbent should maintain accurate, legible research notebooks, analyze and report results to the principal investigator after completion of experiments. The candidate is required to meet weekly with the Principal Investigator to review research results, develop plans for additional experiments and discuss potential new areas of interest.

The incumbent is expected to be an excellent team worker and be willing to seek feedback from senior lab personnel or the supervisor for any questions, troubleshooting, or required training. He/she will also collaborate with other investigators in other laboratories or departments to ensure the success of the project. The candidate should feel comfortable to work with scientists across a broad range of backgrounds.

The incumbent will attend all laboratory and general Vincent Center for Reproductive Biology (VCRB) meetings, participate in laboratory, VCRB and departmental training and educational events (e.g., chemical and biosafety training, animal care practices, etc.), practice laboratory safety in accordance with Mass General and VCRB guidelines, and interact constructively with all laboratory personnel in the VCRB and the Department of Obstetrics and Gynecology.

The position requires:

1. Must be able to work initiatively, accurately, consistently, and independently, display initiative to introduce Innovations to research study, and have good time management skills

2. Have experience in High-throughput screening based on cellular and animal models, data analysis/visualization, and screening results verification. Have experience in using online cancer genetic and genomic databases, NCBI sponsored gene and protein databases, as well as other online databases and tools

3. Have the ability to maintain multiple breeding colonies of mice that are required in his/her project, develop and use laboratory animal models under the direction of the principal investigator, collect tissue samples and prepare for histological and molecule analyses

4. Have experience or ability to: 1) prepare and maintain cell and tissue cultures; 2) perform routine cell biology assays; 3) develop and use cellular and laboratory animal models under the direction of the principal investigator, collect cell and tissue samples and prepare nucleic acid/protein/lipid samples for molecule analysis; 4) perform basic molecular biology assays (e.g., molecular cloning, mutation analyses, site-directed mutagenesis, vector construction, RT-PCR, Western and Northern blotting, EMSA, kinase assays, and ELISA); 5) perform histological analyses (e.g., tissue preparation, sectioning, regular H-E staining, immunohistochemistry, immunocytochemistry and in situ hybridization)

5. Reliably maintain accurate records of experiments performed, attend weekly lab meeting to conduct formal presentations of research methodology, findings and conclusions

6. PC and Mac competency is required

7. Have excellent communication/interpersonal skills, and work cooperatively with others and be willing to learn new techniques.

Requirements

A Ph.D. degree in life science or related area is required.

Please email a CV and cover letter of interest to CWANG34@mgh.harvard.edu indicating that you are applying for the postdoctoral position in Dr. Wang’s lab. Two letters of reference and a brief writing sample will also be requested during the interview process.


Massachusetts General Hospital is a teaching affiliate of Harvard Medical School and an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status or status as an individual with a disability.