Vincent Center for Reproductive Biology
The mission of our center is to overcome infertility, improve health care for non-pregnant and pregnant women, combat gynecologic cancers, and ease the menopausal transition in women through basic, translational and clinical research.
Research Fellow Position in the Edlow Lab
We are recruiting a postdoctoral fellow with expertise in neuroscience to work in the Edlow Laboratory within the Vincent Center for Reproductive Biology on an NIH-funded project focused on brain-placental immune activation in maternal dysmetabolism. The ideal candidate will also have a background in immunology.
Our research broadly focuses on the programming effects of maternal obesity/overnutrition on fetal and offspring brain development and behavior, and the placenta-brain connection. We utilize pre-clinical models to explore mechanisms underlying neurodevelopmental morbidity in obesity-exposed offspring, including but not limited to neuroinflammation, neuroimmune interactions, and the impact of offspring sex.
Our laboratory is affiliated with Harvard Medical School and Massachusetts General Hospital.
Applicant should have a PhD, ideally in neuroscience, although applicants with a PhD and extensive experience with rodent models, molecular techniques, and immunohistochemistry are also encouraged to apply.
View the Complete Job Description
The Edlow Laboratory for basic and translational research is sited in the Vincent Center for Reproductive Biology (VCRB) on the main campus of Massachusetts General Hospital.
Ongoing studies focus on the neurodevelopmental programming effects of maternal obesity and maternal high-fat diet during pregnancy and lactation. The work is primarily with a mouse model of maternal diet-induced obesity.
We evaluate fetal, juvenile, and adult offspring brain development using molecular and immunohistochemical techniques, as well as neurobehavioral testing. Areas of focus include: (1) the effects of maternal diet-induced obesity on offspring cognition and mood outcomes (anxiety, depression), particularly as they relate to neuroinflammation and brain-immune interactions; (2) Developmental programming of offspring feeding behaviors (reward-based feeding governed by the mesolimbic dopamine circuit) and offspring metabolic parameters (including insulin resistance, body fat composition, and dysregulation of leptin, ghrelin, and other peripheral and central hormonal signaling); (3) Utilizing novel targeted therapeutics to improve offspring neurodevelopmental outcomes; and (4) Elucidating the role of fetal and offspring sex in mediating the effects of maternal diet-induced obesity on neurodevelopment.
The position requires:
- Extensive experience with mouse models and handling, including rodent surgery
- Experience with brain retrieval, tissue preservation for immunohistochemical analyses and RNA/DNA/protein assays, brain sectioning and tissue staining, and neurobehavioral testing is strongly preferred
- Experience with flow cytometry and/or FACS is preferred
- Skill in collection, organization, management, and analysis of complex data sets including record-keeping for large mouse colonies and neurobehavioral test results, among others
- Skill in experimental design, protocol development, and troubleshooting
- Skill in data analysis using statistical analytical tools is required. Experience with Graphpad Prism and/or SPSS/STATA/SAS is preferred
- Experience preparing manuscripts for publication, experience with review and summarization of relevant literature for manuscript background and grant preparation
- Preparation of study findings and presentation at professional meetings will also be strongly encouraged
There are many opportunities for education and growth in our multidisciplinary, collaborative research program that brings together a diverse group of obstetrician-gynecologists, neuroscientists, immunologists, endocrinologists, animal neuroimagers at the world-class Athinoula Martinos Center for Brain Imaging, and translational and clinical researchers at the Women Heart Brain Global Initiative.
How to Apply
Please email a CV and cover letter of interest to Ms. Lindsay Theriault, Administrative Assistant for the Vincent Center of Reproductive Biology, at email@example.com, indicating that you are applying for the postdoctoral position in Dr. Edlow’s lab.
Two letters of reference and a brief writing sample will also be requested during the interview process.
Dr. Kislal completed her undergraduate studies in Biology at Hacettepe University in Turkey. After graduating, she completed a PhD at Pennsylvania State University in experimental psychology with special emphasis on context aversion learning, working in the laboratory of Dr. David Blizard. She also had the opportunity to work in the National Institute of Genetics in Mishima, Japan, where she studied the genetics of bitter taste in mice. After completing her PhD, to further explore the interactions between animal behavior and neuroscience, she joined Dr. Mehrdad Shamloo’s laboratory at Stanford University as a postdoctoral fellow. While in Dr. Shamloo’s laboratory she focused on novel therapeutic approaches in experimental models of stroke. She came back to the United States from Ankara to make Boston her new home while working as a post-doctoral fellow in the Edlow lab.
Pablo is a Research Technician II working in the Edlow Laboratory. Pablo came to us from Madrid, Spain, where he studied at the Universidad Autonoma de Madrid, earning a BSc in Biochemistry and Molecular Biology and a MSc in Pharmacological Research. Here, he works with Dr. Edlow and staff to study the effects of maternal obesity on fetal brain development and offspring behavior.
Research Fellow Position in the Wang Lab
A postdoctoral research fellow position is available in the Wang Lab at the Vincent Center for Reproductive Biology (VCRB), Department of Obstetrics and Gynecology. Our research mainly focuses on discovering new strategies to improve prevention, early detection, and treatment of ovarian and cervical cancers.
The ideal applicant will have a graduate degree in the biological sciences (PhD, MD, or MD/PhD) with proven proficiency in cell/molecular techniques. Strong background on immunology and cancer immunotherapy is preferred.
How to Apply
Candidates with experience in generating transgenic mouse model are strongly encouraged to apply. Interested candidates should send a cover letter, curriculum vitae and contact information of three professional references (names, address, phone and e-mail) to Ms. Lindsay Theriault, Administrative Assistant, Vincent Center for Reproductive Biology, Massachusetts General Hospital, THR-901, 55 Fruit Street, Boston, MA 02114.
Massachusetts General Hospital is a teaching affiliate of Harvard Medical School and an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status or status as an individual with a disability.
A number of dynamic and passionate postdocs have come together to form a postdoctoral association at Massachusetts General Hospital, named the Mass General Postdoc Association - MGPA. This association will serve our workplace community for research and career related matters, and it will also provide a platform for interaction of all postdoctoral research fellows.