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A study led by Massachusetts General Hospital investigators finds evidence that the process of synaptic pruning, a normal part of brain development during adolescence, is excessive in individuals with schizophrenia. The study is the first to directly observe excessive synaptic pruning in cells from patients with schizophrenia.
– Health plans – entities that cover the costs of medical care – accounted for the greatest number of patient records breached over the past seven years, according to an analysis of U.S. health care data conducted by two Massachusetts General Hospital physicians.
A genomic study using a novel method of enrolling participants - using data gathered by a consumer genomics company - has identified for the first time 15 regions of the genome that appear to be associated with depression in individuals of European ancestry.
An analysis of medical records data from three Massachusetts health care systems finds no evidence that prenatal exposure to antidepressants increases the risk for autism and related disorders or for attention-deficit hyperactivity disorder.
Previous studies that have suggested an increased risk of autism among children of women who took antidepressants during pregnancy may actually reflect the known increased risk associated with severe maternal depression.
Roy Perlis, MD, MSc, director of the MGH Psychiatry Center for Experimental Drugs and Diagnostics, explains a recent study published in the journal BMJ that he led and
outlines what it means for people who take antidepressant medications.
An analysis of the medical records of more than 38,000 patients by MGH investigators clarifies the contribution of citalopram and other antidepressants to lengthening of the QT interval, an aspect of the heart's electrical activity that – when prolonged – may increase the risk of dangerous arrhythmias.
In General awards and honors
Among patients with depression, the presence of symptoms associated with bipolar disorder does not appear to be associated with treatment resistance, according to a study from MGH investigators. However, many patients with depression also report psychotic-like symptoms, such as hearing voices or believing they are being spied on or plotted against, and those patients are less likely to respond to treatment.
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