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Research at Mass General
The Transplantation Biology Research Center (TBRC) Laboratories in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital comprises two laboratories, the Genetic Engineering Laboratory and the Organ Transplantation Tolerance and Xenotransplantation Laboratory.
These laboratories utilize partially inbred miniature swine as preclinical large animal models in allotransplantation studies. Three herds of miniature swine homozygous for different sets of histocompatibility antigens at the major histocompatibility complex (MHC) have been developed by David H. Sachs, MD, Scientific Director of the CTS, over the past 40 years. These animals show many similarities to human beings, both immunologically and physiologically, facilitating their potential use both as a model for allotransplantation studies and as xenograft donors.
David H. Sachs, MD Scientific Director, Center for Transplantation Sciences (CTS)Director, Transplantation Biology Research Center (TBRC) Laboratories, CTSImmunologist, Massachusetts General Hospital Paul S. Russell/Warner-Lambert Professor of Surgery, Harvard Medical SchoolView publications
Rebecca Brophy, Senior Executive Assistant
David H. Sachs, MD, graduated from Harvard College in 1963, summa cum laude, with a Bachelor of Arts in chemistry, in 1964 with a DES in organic chemistry from the University of Paris and in 1968 with a Doctor of Medicine, magna cum laude, from Harvard Medical School.
From 1968 to 1970, Dr. Sachs trained as a surgical intern and research fellow in transplantation at Massachusetts General Hospital. He then moved to the National Institutes of Health, where he developed a program in transplantation research. In 1991, he returned to Mass General as director of the Transplantation Biology Research Center, now known as the CTS, and the first Paul S. Russell/Warner-Lambert Professor of Surgery at Harvard Medical School.
Dr. Sachs has published more than 700 articles in scientific journals. His research achievements include:
Dr. Sachs is one of the three North American editors of Transplantation and was the founding editor of Xenotransplantation.
Dr. Sachs was elected to the Institute of Medicine of the National Academy of Sciences in 1996. He has received the Jean Borel Award in Transplantation, the ASTP/Novartis Established Investigator Award, The Medical Foundation Award and the Roche Ernest Hodge Memorial Award (formerly called the Roche AST Distinguished Achievement Award), the highest award bestowed by the American Society of Transplantation. Dr. Sachs was awarded an Honorary Degree from University of Nantes, France (2006), the Martin Prize for Excellence in Clinical Research (2009) and the Starzl Prize (2011). In 2014, he was honored with the Medawar Prize, awarded by the Transplantation Society.
Robert J. Hawley, PhDKazuhiko Yamada, MD, PhD
The Transplantation Biology Research Center (TBRC) Laboratories lead the following projects:
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