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Research at Mass General
The Lazar Lab for Meditation Research at Massachusetts General Hospital studies the impact of yoga and meditation on cognitive and behavioral functions using scientifically validated brain imaging technologies.
Our results provide compelling evidence that meditation can produce experience-based structural alterations in the brain. We also found indications that meditation may slow down the age-related atrophy of certain areas of the brain.
Sara Lazar, PhD Associate Researcher in Psychiatry, Massachusetts General Hospital Assistant Professor in Psychology, Harvard Medical School
The focus of Dr. Lazar’s research is to elucidate the neural mechanisms underlying the beneficial effects of yoga and meditation, both in clinical settings and in healthy individuals. She has been practicing yoga and mindfulness meditation since 1994. Her research has been covered by numerous news outlets including The New York Times, USA Today, CNN, and WebMD, and her work has been featured in a display at the Boston Museum of Science.
Tanya Datta Clinical Research Coordinator Tanya graduated from the University of Pennsylvania in 2017 where she received her bachelor’s degree in the biological basis of behavior (behavioral neuroscience) with a minor in Japanese. She is currently co-lead on the brain training study for older adults. Tanya plans on attending medical school in the future and hopes to bring mindfulness into the care of patients and patient-providers alike.
Jonathan Greenberg, PhD Postdoctoral Research Fellow Massachusetts General Hospital and Harvard Medical School
Dr. Greenberg’s work focuses primarily on cognitive and neural effects of mindfulness practice. Jonathan is particularly interested in the mechanisms underlying the efficacy of mindfulness practice in treating and preventing depression, enhancing cognitive functioning, improving emotion regulation, and promoting well-being. Jonathan's background is in clinical psychology and treating individuals dealing with mood and anxiety related conditions. He has been personally involved in mindfulness practice since 2003 and has since integrated his interest in mindfulness into his clinical and academic work.
Robert Kaufman Clinical Research Coordinator Rob is the co-lead on a brain training study for older adults. He graduated from Ohio State University with a Bachelor of Science degree in Behavioral Neuroscience and Psychology with Research Distinction. He plans on attending graduate school in the future to continue his neuroscience research career.
Gunes Sevinc, PhD Postdoctoral Research Fellow, Massachusetts General Hospital and Harvard Medical School
Dr. Sevinc’s PhD dissertation focused on neural networks associated with moral cognition, especially those involved in the detection of morally relevant stimuli. Her current research interests include the relationship between mindfulness meditation and moral cognition. She is specifically interested in the structural and functional changes associated with mindfulness practice as they relate to moral behavior and prosociality. Currently, she is utilizing multivariate neuroimaging analysis methods to investigate the effects of mindfulness practice in improving cognition.
This project is a large study of the impact of meditation training on cognition and brain structure in healthy older adults. The study will address the questions: Can older adults still experience the changes in brain structure following meditation training that were found in younger subjects? Can meditation slow the normal decline in cognition that happens as we grow older?
This project in collaboration with the Benson Henry Mind Body Medical Institute is comparing changes in brain structure and function following randomization to yoga, the Relaxation Response, or a control program. Changes in neural structure and function will be compared to changes in stress biomarkers.
Sevinc G, Hölzel BK, Hashmi J, Greenberg J, McCallister A, Treadway M, Schneider ML, Dusek JA, Carmody J, Lazar SW. Common and Dissociable Neural Activity After Mindfulness-Based Stress Reduction and Relaxation Response Programs. Psychosom Med 2018 Jun;80(5):439-451.
Greenberg J, Romero VL, Elkin-Frankston S, Bezdek MA, Schumacher EH, Lazar SW. Reduced interference in working memory following mindfulness training is associated with increases in hippocampal volume.Brain Imaging Behav. 2018 Mar 17.
Afonso RF, Balardin JB, Lazar SW, Sato JR, Igarashi N, Santaella DF, Lacerda SS, Amaro E, Kozasa EH. Greater cortical thickness in elderly female yoga practitioners–a cross-sectional study. Frontiers in Aging Neuroscience 9,201, 2017
Van Dam N, van Vugt M, Vago D, Schmalzl L, Saron C, Olendzki A, Meissner T, Lazar S, Kerr C, Gorchov J, Fox K, Field B, Britton W, Brefczynski-Lewis, J, Meyer D. Mind the hype: A critical evaluation and prescriptive agenda for scientific research on mindfulness and meditation. Perspectives on Psychological Science
Greenberg J, Shapiro BG, Mischoulon D, et al. Mindfulness-based cognitive therapy for depressed individuals improves suppression of irrelevant mental-sets. European Archives of Psychiatry and Clinical Neuroscience. 2016 :1-6. Publisher's Version |Abstract
de Jong M, Lazar S, Hug K, Mehling WE, Hölzel BK, Sack AT, Peeters F, Ashih H, Mischoulon D, Gard T. Effects of mindfulness-based cognitive therapy on body awareness in patients with chronic pain and comorbid depression. Frontiers in Psychology. 2016;7 :967. | Abstract
Hölzel BK, Brunsch V, Gard T, Greve DN, Koch K, Sorg C, Lazar SW, Milad MR. Mindfulness-based stress reduction, fear conditioning, and the uncinate fasciculus: A pilot study. Frontiers in Behavioral Neuroscience. 2016;10 :124. Publisher's Version | Abstract
Good DJ, Lyddy CJ, Glomb TM, Bono JE, Brown KW, Duffy MK, Baer RA, Brewer JA, Lazar SW. Contemplating mindfulness at work an integrative review. Journal of Management [Internet]. 2015 :0149206315617003. Publisher's Version | Abstract
Gard T, Taquet M, Dixit R, Hölzel BK, Dickerson BC, Lazar SW. Greater widespread functional connectivity of the caudate in older adults who practice kripalu yoga and vipassana meditation than in controls. Frontiers in Human Neuroscience [Internet]. 2015;9 (137). Publisher's Version | Abstract
Desbordes G, Gard T, Hoge EA, Hölzel BK, Kerr C, Lazar SW, Olendzki A, Vago DR. Moving beyond mindfulness: defining equanimity as an outcome measure in meditation and contemplative research. Mindfulness [Internet]. 2015;6 (2) :356-372. Publisher's Version | Abstract
Singleton O, Hölzel BK, Vangel M, Brach N, Carmody J, Lazar SW. Change in brainstem gray matter concentration following a mindfulness-based intervention is correlated with improvement in psychological well-being. Frontiers in Human Neuroscience. 2014;8. Publisher's Version
Gard T, Taquet M, Dixit R, Hoelzel BK, De_montjoye Y, Brach N, Salat D, Dickerson BC, Gray JR, Lazar SW. Fluid intelligence and brain functional organization in aging yoga and meditation practitioners. Frontiers in Aging Neuroscience. 2014;6 :76. Publisher's Version |Abstract
Deckersbach T, Hölzel B, Eisner L, Lazar SW, Nierenberg AA. Mindfulness-Based Cognitive Therapy for Bipolar Disorder. 2014.
Gard T, Hölzel BK, Lazar SW. The potential effects of meditation on age‐related cognitive decline: a systematic review. Annals of the New York Academy of Science. 2014;1307 (1) :89-103. Publisher's Version|Abstract
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