Translational Genomics in the Laboratory and in the Clinic

The Talkowski Laboratory is interested in understanding the consequence of genomic variation on human disease.

We study the genetic etiology of disorders affecting prenatal, neonatal, and early childhood development, particularly autism spectrum disorder (ASD) and related neurodevelopmental and psychiatric disorders.

Our research program integrates a molecular genomics wet laboratory with a computational genomics group.

The lab is composed of undergraduate and graduate students, post-baccalaureate researchers, postdoctoral fellows, and senior staff scientists performing human genomic research in four primary domains:

  1. Delineation of genomic variation and genome biology
  2. Discovery of genes that can contribute to human disease when altered
  3. Functional genomic characterization of genetic lesions and the networks that they disrupt
  4. Translation of genomics technology development into new genetic diagnostic methods

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