About David Pyle, MD, PhD

I am an allergy/immunology physician who specializes in the care of pediatric food allergy. I was born and raised in Texas and attended UT Southwestern Medical School obtaining an MD degree as well as a PhD in Immunology. After completing my residency training in Pediatrics at Yale-New Haven Hospital, I joined the Allergy and Immunology department at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) as a Clinical and Research Fellow. I completed my fellowship training in June 2020 and transitioned to a faculty position as Assistant Instructor in Pediatrics at MGH and HMS. In my current role, I provide clinical care in the Pediatric Allergy and Immunology Clinic and conduct research on oral immunotherapy for food allergy to enhance our knowledge and the quality of patient care.

My clinical interests and expertise revolve around the care of pediatric food allergies. During my fellowship at MGH, I was actively involved in clinical work, providing treatment for adult and pediatric patients with a variety of allergic or immunologic conditions. I have identified pediatric food allergy as my area of focus and have worked to gain clinical experience in this area. I am involved in several clinical trials around food allergy oral immunotherapy as well as participating in the clinical Peanut Oral Immunotherapy program with the MGH Food Allergy Center. I also participate in research within the MGH Center for Immunologic and Inflammatory Diseases as part of the Shreffler Lab. My research focuses on the use of bioinformatics and data science to gain insight into the mechanisms and outcomes of oral immunotherapy for food allergy. 

Clinical Interests:



Boston: Massachusetts General Hospital

Mass General for Children: Pediatric Allergy & Immunology
275 Cambridge St.
Professional Office Building
Suite 530
Boston, MA 02114
Phone: 617-726-8707

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Waltham: Mass General Waltham

Allergy Associates at Mass General Waltham
52 Second Ave.
Suite 2600
Waltham, MA 02451
Phone: 781-487-3838

Medical Education

  • M.D.; Ph.D., UT Southwestern Medical School
  • Residency, Yale New Haven Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Allergy and Immunology, American Board of Allergy and Immunology
  • Pediatrics, American Board of Pediatrics

Accepted Insurance Plans

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I am a member of the Shreffler Laboratory within the MGH Center for Immunologic and Inflammatory Diseases. The Shreffler Laboratory research program involves a combination of approaches, primarily with human samples and often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens. We work together with leading clinical investigators around the world as part of the Consortium for Food Allergy Research and the Inner City Asthma Consortium and the newly established Food Allergy Research Center at Mass General. 

My research focuses on the use of bioinformatics and data science to gain insight into the mechanisms and outcomes of oral immunotherapy for food allergy. By analyzing changes in gene expression over the course of peanut oral immunotherapy, we hope to identify the mechanisms by which oral immunotherapy induces tolerance and highlight ways in which the process can be optimized. I also participate in active clinical trials in the Shreffler Laboratory, supervising clinical visits as well as providing data management support.


  • Pyle DM, Yang VS, Gruchalla RS, Farrar JD, and Gill MA. IgE cross-linking critically impairs human monocyte function by blocking phagocytosis. J Allergy Clin Immunol. 2013 Feb;131(2):491-500.e1-5. PMID: 23374271.


    Rowe RK*, Pyle DM*, Tomlinson AR, Lv T, Hu Z, and Gill MA. IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol. 2017 Jul;140(1):294-298.e8. PMID: 28087327.


    Rowe RK, Pyle DM, Farrar JD, and Gill MA. IgE-mediated regulation of IL-10 and type I IFN enhances rhinovirus-induced Th2 differentiation by primary human monocytes. Eur J Immunol. 2020 Oct;50(10):1550-1559.  PMID: 32383224.

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