David Pyle, MD, PhD
David Pyle, MD, PhD
Departments, Centers, & Programs:
Boston: Massachusetts General Hospital
Mass General for Children: Pediatric Allergy & Immunology
275 Cambridge St.
Professional Office Building
Boston, MA 02114
Waltham: Mass General Waltham
Allergy Associates at Mass General Waltham
52 Second Ave.
Waltham, MA 02451
- M.D.; Ph.D., UT Southwestern Medical School
- Residency, Yale New Haven Hospital
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Allergy & Immunology, American Board of Allergy and Immunology
- Pediatrics, American Board of Pediatrics
I am a member of the Shreffler Laboratory within the MGH Center for Immunologic and Inflammatory Diseases. The Shreffler Laboratory research program involves a combination of approaches, primarily with human samples and often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens. We work together with leading clinical investigators around the world as part of the Consortium for Food Allergy Research and the Inner City Asthma Consortium and the newly established Food Allergy Research Center at Mass General.
My research focuses on the use of bioinformatics and data science to gain insight into the mechanisms and outcomes of oral immunotherapy for food allergy. By analyzing changes in gene expression over the course of peanut oral immunotherapy, we hope to identify the mechanisms by which oral immunotherapy induces tolerance and highlight ways in which the process can be optimized. I also participate in active clinical trials in the Shreffler Laboratory, supervising clinical visits as well as providing data management support.
Pyle DM, Yang VS, Gruchalla RS, Farrar JD, and Gill MA. IgE cross-linking critically impairs human monocyte function by blocking phagocytosis. J Allergy Clin Immunol. 2013 Feb;131(2):491-500.e1-5. PMID: 23374271.
Rowe RK*, Pyle DM*, Tomlinson AR, Lv T, Hu Z, and Gill MA. IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol. 2017 Jul;140(1):294-298.e8. PMID: 28087327.
Rowe RK, Pyle DM, Farrar JD, and Gill MA. IgE-mediated regulation of IL-10 and type I IFN enhances rhinovirus-induced Th2 differentiation by primary human monocytes. Eur J Immunol. 2020 Oct;50(10):1550-1559. PMID: 32383224.