Irritable Bowel Syndrome (IBS) is a common, chronic, debilitating condition that can have a major impact on an individual’s quality of life. In this Massachusetts General Hospital Blum Center presentation from April 26, 2023, Sarah Di, PA-C, and Luyang Liu, MPH, PA-C, discuss in detail the subtypes of IBS and how it differs from other similar gastrointestinal conditions. Additionally, they review common symptoms of IBS, and how it is diagnosed and managed.