In this Massachusetts General Hospital Blum Center presentation from October 18, 2021, Brian Skotko, MD, MPP, and Clorinda Cottrell, MSW, LICSW, provide an overview of the Mass General Down Syndrome Program, dispel common myths and misperceptions about Down syndrome, and offer information and understanding about the interplay between medical and mental wellness across the lifespan. They also discuss ways to support individuals, families and providers in the healthcare setting.