In this Massachusetts General Hospital Blum Center presentation from August 10, 2021, Maureen Leonard, MD, MMSc, and Stephanie Harshman, PhD, RD, LD, from the Center for Celiac Research and Treatment at MassGeneral Hospital for Children discuss the two most common gluten related disorders—celiac disease and non-celiac gluten sensitivity. They review the common misconceptions, signs and symptoms, diagnosis and management of these disorders.