Search Cancer Clinical Trials

Mass General Brigham Cancer Institute offers patients access to a wide variety of clinical trials of promising new therapies. Use the search tool to find open protocols for your type of cancer.
27 results
  • Lung Cancer, Pancreatic Cancer, Colorectal Cancer

25-286          Phase II

A Phase 1/2a, Open-label Study of VS-7375, a KRAS G12D (ON/OFF) Inhibitor, as Monotherapy and in Combination, in Patients with Advanced KRAS G12D-Mutant Solid Tumors

  • Lung Cancer, Colorectal Cancer, Pancreatic Cancer

25-531          Phase I

A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-11818 in Subjects with Advanced KRAS Mutant Cancers

  • Colorectal Cancer, Lung Cancer

21-398          Phase I

A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors

  • Colorectal Cancer, Lung Cancer, Pancreatic Cancer

24-649          Phase I

A Phase 1a/1b Study of the pan-KRAS Inhibitor LY4066434 in Participants with KRAS Mutant Solid Tumors

  • Lung Cancer, Colorectal Cancer, Breast Cancer

24-514          Phase I

A Phase 1a/1b Study of the PI3Ka:RAS Breaker BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)

  • Thymoma, Ovarian Cancer, Melanoma, Lung Cancer, Kidney Cancer, Head and Neck Cancer, Gastric (Stomach) Cancer, Rectal Cancer, Esophageal Cancer, Colorectal Cancer

23-423          Phase I

A Phase I, Open-label, Multi-center Study of KFA115 as a Single Agent and in Combination with Pembrolizumab in Patients with Select Advanced Cancers

  • Colorectal Cancer

21-529          Phase I

A PHASE I/Ib GLOBAL, MULTICENTER, OPEN-LABEL UMBRELLA STUDY EVALUATING THE SAFETY AND EFFICACY OF TARGETED THERAPIES IN SUBPOPULATIONS OF PATIENTS WITH METASTATIC COLORECTAL CANCER (INTRINSIC)

  • Colorectal Cancer, Pancreatic Cancer

24-325          Phase II

A Platform Study of RAS(ON) Inhibitors to Treat Patientswith Gastrointestinal Solid tumors

  • Metastatic/Advanced Cancer, Head and Neck Cancer, Gastric (Stomach) Cancer, Endometrial Cancer, Colorectal Cancer, Cervical Cancer, Breast Cancer, Ovarian Cancer

23-618          Phase I

A Study to Evaluate the Safety and Tolerability of the Covalent Phosphoinositide-3-Kinase (PI3K)-alpha Inhibitor, TOS-358, in Adult Subjects with Select Solid Tumors

  • Colorectal Cancer, Pancreatic Cancer, Ovarian Cancer, Lung Cancer

23-242          Phase I

An Open-Label Phase 1 Dose-Escalation and Expansion Study Investigating the Safety, Pharmacokinetics, Pharmacodynamics, and Activity of PRTH-101 Alone or in Combination with Pembrolizumab in Adults with Locally Advanced or Metastatic Solid Tumors

Showing 1 - 10 of 27 results