Center for Cancer Research
Advancing Cancer Research
The mission of the Mass General Center for Cancer Research is to conduct fundamental basic and translational research on cancer, through a highly innovative, multi-disciplinary and collaborative environment. We are committed to teaching and training the next generation of cancer researchers, within a diverse and inclusive research community. Through scientific innovation, we strive for global impact on the treatment, early diagnosis and prevention of all forms of cancer.
Welcome to the Center for Cancer Research
View a welcome message from Daniel Haber, MD, PhD, Director, Center for Cancer Research.
View Our Investigators
The Center for Cancer Research has a dedicated faculty of over 40 independent investigators using state-of-the-art tools in a variety of fields.
Center for Cancer Research Annual Report
View our 2022 annual report (PDF is large, please be patient as it loads).
News & Events
View research highlights, news and featured publications from the Center for Cancer Research.
2022-2023 Center for Cancer Research Seminar Series-
The Center for Cancer Research Seminar Series occurs weekly and provides an opportunity for the MGH research community to learn from national & international leaders in cancer research.
Extracellular matrix proteins prevent the immune system’s natural killer cells from killing their targets in peripheral tissues
NK cells are known for their innate ability to kill cancer and virus-infected cells. However, they fail to kill their targets in solid organs. In a MAR 2022 paper published in Science Advances, Bunting, et al. provide a novel explanation for this fundamental dilemma in the field of NK cell biology.
Newly discovered DNA repair mechanisms point to potential therapy targets for cancer and neurodegenerative diseases
Raul Mostoslavsky, MD, PhD and colleagues at MGH and Harvard have developed a highly sensitive method for visualizing DNA repair mechanisms at work.
The mutation-independent immunogenic effect of environmental carcinogens blocks cancer metastasis
In a June 2021 Science Advances paper, Li et al. describe a distinct consequence of exposure to carcinogen that can have significant immunologic implications: the nongenetic induction of a chemokine called CCL21 in breast cancer cells that developed following an exposure to a chemical carcinogen.
Lee Zou, PhD and Raul Mostoslavsky, MD, PhD Named Scientific co-Directors
Congratulations to Lee Zou, PhD and Raul Mostoslavsky, MD, PhD who will serve as Scientific co-Directors of the Mass General Cancer Center and Center for Cancer Research.
Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells
A team at Mass General has devised a new ultrahigh-throughput microfluidic chip (the LPCTC-iCHIP) that improves sensitivity of CTC-based assays 100-fold as compared to existing approaches. The team’s paper appeared recently in the May 2020 issue of Proceedings of the National Academy of Sciences.
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma
Cancer researchers have identified changes in lung cancer-promoting genes that may allow the disease to metastasize to the brain. Their work, which points to possible therapies for preventing or treating brain metastases from lung cancer, is described in the March 2020 issue of Nature Genetics.
Leading-edge Science Coupled with Innovative Care
Our vision is to contribute toward the eradication of cancer and lessen its burden across all communities, through scientific innovation and the rapid application of new discoveries.
Support the Center for Cancer Research
When you support the Center for Cancer Research you are enabling discoveries that will lead to effective new weapons in the battle against cancer.
#1 Research Hospital in America
Mass General is the #1 hospital in New England based on U.S. News & World Report Best Hospitals for 2022-2023.
Education & Training at the Cancer Center
A world leader in cancer research & comprehensive cancer treatment, we are dedicated to educating the next generation of cancer specialists.
Data Analyst Position
Unique opportunity to join an interdisciplinary team bridging the Harvard Medical School, the Massachusetts General Hospital, and the Broad Institute of Harvard and MIT. The Rheinbay Lab and Lawrence Lab at the Mass General Cancer Center seek well-qualified candidates to join a team of computational biologists working at the forefront of cancer research and treatment. We use computation as a powerful microscope to study both the fundamental biology of cancer initiation and progression, as well the diagnosis and treatment of cancer patients in the hospital setting. Learn more on the Rheinbay Lab and Lawrence Lab pages.
Postdoc Fellow Positions
Center for Cancer Research
The Center for Cancer Research's faculty collaborate with Mass General's leading oncologists, surgeons, radiologists, pathologists and other health care professionals to advance the frontiers of cancer medicine.