Center for Cancer Research
Advancing Cancer Research
The mission of the Mass General Center for Cancer Research is to understand cancer at the molecular, cellular, tissue, and whole organism levels and to apply that knowledge to advance the treatment and prevention of human cancer.
News & Events
View the latest research highlights and featured publications from the Center for Cancer Research.
Immunity to Commensal Virome Blocks Cancer
In an Oct 2019 paper published in Nature, Strickley, Messerschmidt et al. investigated the role HPVs play in the development of skin cancer. Using a novel skin colonization model, they show that adaptive immunity against papillomavirus infection is able to protect the host from developing cancer.
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.
Mass General investigators have created a new method that could make immune therapy more effective again brain tumors and expand its use against other types of solid tumors. Their study is published in the July 2019 issue of Nature Biotechnology.
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
In this July 2019 paper published in Cell, a group of researchers from the Suva lab identified four different states of glioblastoma, and demonstrated a remarkable level of plasticity between these states.
Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.
In a June 2019 paper published in Cell, Yan, Langenau and coworkers show that they can engraft a wide array of human tumors in optically clear zebrafish. The advantages of this system for imaging mean that it is readily possible to visualize dynamic changes in single engrafted cells.
Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features.
In this 2019 paper published in Science, Dr. Zou and Dr. Lawrence showed that some nominated cancer drivers (e.g. a hotspot in gene MB21D2) are passenger hotspots, and would likely not be worthwhile targets for further study. These insights will improve ability to detect the true drivers of cancer.
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.
In a May 2019 paper published in Nature, Grünewald et al investigated the effects of cytosine base editors for RNA and DNA editing. They show that targeting of rat APOBEC1 can cause extensive transcriptome-wide deamination of RNA cytosines in human cells, inducing tens of thousands of C-to-U edits.
Leading-edge Science Coupled with Innovative Care
The Center for Cancer Research serves as the the scientific engine for discovery for the Mass General Cancer Center.
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Education & Training at the Cancer Center
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Postdoc Fellow Positions
- Postdoctoral Research Fellowships in Cancer Immunology
- Postdoctoral Research Position in the Iliopoulos Lab