The Center for Cancer Research has a dedicated faculty of over 40 independent investigators using state-of-the-art tools in a variety of fields: genetics, genomics, developmental biology, transgenic science, cancer immunology, advanced microscopy, computational biology, protein chemistry, engineering, pharmacology, and other fields.

 

Daniel Haber

Daniel A. Haber, MD, PhD
Director, Massachusetts General Hospital Cancer Center
Kurt J. Isselbacher Professor of Oncology

Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.

 


Martin Aryee, PhD*

Martin Aryee, PhD*
Assistant Professor of Pathology, Massachusetts General Hospital Cancer Center

Research topics include: statistical tools for mapping genomic and epigenomic landscapes.

 


Nabeel Bardeesy, PhD

Nabeel Bardeesy, PhD
Associate Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: pancreatic ductal adenocarcinoma.

 


Liron Bar-Peled, PhD

Liron Bar-Peled, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: Transcription factor NRF2, anti-oxidant response, stress signaling.

 


Cyril Benes, PhD

Cyril Benes, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center

Research topics include: the response to cancer therapeutics, the molecular basis of sensitivity to specific drugs and how to identify the genetic variations affecting the response to targeted therapies.

 


Bradley Bernstein, MD, PhD*

Bradley Bernstein, MD, PhD*
Professor of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: high-throughput, sequencing-based technologies to characterize chromatin structure genome-wide in human and mouse.

 


Priscilla K. Brastianos, MD

Priscilla K. Brastianos, MD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School

Research topics include: genomic drivers of human brain tumors.

 


Ryan Corcoran, MD, PhD

Ryan Corcoran, MD, PhD
Associate Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: developing new and effective therapies for gastrointestinal cancers.

 


Shadmehr (Shawn) Demehri, M.D., Ph.D.

Shadmehr (Shawn) Demehri, M.D., Ph.D.
Assistant Professor of Dermatology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: role of the immune system in regulating the early stages of cancer development.

 


Nicholas Dyson, PhD

Nicholas Dyson, PhD
Professor of Medicine, Harvard Medical School
Mary B. Saltonstall Chair in Oncology, Harvard Medical School
Scientific Director, MGH Cancer Center
James and Shirley Curvey MGH Research Scholar

Research topics include: E2F - and pRB-; tumorigenesis.

 


Andrew Elia, MD, PhD

Andrew Elia, MD, PhD
Assistant Professor of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.

 


Leif Ellisen, MD, PhD

Leif Ellisen, MD, PhD
Professor of Medicine, Director of Breast Medical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: P53 and human tumorigenesis; breast cancer.

 


David Fisher, MD, PhD

David Fisher, MD, PhD
Chief, Department of Dermatology, Edward Wigglesworth Professor of Dermatology, Harvard Medical School

Research topics include: cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood.

 


Gad A. Getz, PhD*

Gad A. Getz, PhD*
Paul Zamecnik Chair in Cancer Research, Professor of Pathology and Director of BioInformation, Massachusetts General Hospital Cancer Center, and Department of Pathology, Harvard Medical School

Research topics include: cancer genome analysis.

 


Timothy Graubert, MD

Timothy Graubert, MD
Jon and JoAnn Hagler Chair in Hematology-Oncology
Program Director, Hematologic Malignancies, Cancer Center
Associate Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.

 


Wilhelm Haas, PhD

Wilhelm Haas, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: quantitative mass spectrometry-based proteomics to study the cellular pathways that characterize cancer cells.

 


Nir Hacohen, PhD

Nir Hacohen, PhD
Director, Center for Cancer Immunology
Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School
Senior Member, Broad Institute

Research topics include: developing new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.

 


Aaron Hata, MD, PhD

Aaron Hata, MD, PhD
Assistant Professor of Medicine, Harvard Medical School
Assistant Physician in the Division of Hematology and Oncology at the Massachusetts General Hospital

Research topics include: understanding the biological underpinnings of sensitivity and resistance to kinase inhibitor targeted therapies in lung cancers with specific genetic abnormalities (EGFR mutations, ALK translocations, KRAS mutations).

 


Konrad Hochedlinger, PhD**

Konrad Hochedlinger, PhD**
Professor of Medicine and Regenerative Medicine, Department of Molecular Biology, Center for Regenerative Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, and FAS, HU

Research topics include: pluripotency and nuclear reprogramming.

 


Hanno Hock, MD, PhD**

Hanno Hock, MD, PhD**
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: transcription factors in blood development and leukemia.

 


Jonathan G. Hoggatt, PhD

Jonathan G. Hoggatt, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center; Center for Transplantation Sciences, Harvard Medical School

Research topics include: stem cell niche regulatory mechanisms that govern tissue regeneration.

 


A. John Iafrate, MD, PhD*

A. John Iafrate, MD, PhD*
Professor of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.

 


Othon Iliopoulos, MD

Othon Iliopoulos, MD
Associate Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: understanding the biochemical mechanisms of cancer angiogenesis and cancer metabolism in order to identify and validate new targets for treatment of Renal Cell Carcinoma (RCC).

 


Russell Jenkins, MD, PhD

Russell Jenkins, MD, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: PD-1, CTLA-4, immunotherapy, tumor microenvironment, organotypic tumor spheroids, 3D culture, microfluidics, cytokines.

 


J. Keith Joung, MD, PhD*

J. Keith Joung, MD, PhD*
Professor of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: developing technologies for genome engineering using artificial "designer" DNA-binding domains.

 


Li Lan, MD, PhD***

Li Lan, MD, PhD***
Assistant Professor in Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research Topics Include: Oxidative DNA damage, RNA-mediated HR pathway, ROS-Induced R Loops, Telomere dysregulation.

 


David Langenau, PhD*

David Langenau, PhD*
Associate Professor of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.

 


Michael S. Lawrence, PhD

Michael S. Lawrence, PhD
Assistant Professor of Pathology, Harvard Medical School
Assistant Geneticist at the Mass General Cancer Center

Research topics include: using computation as a powerful microscope to study the processes of DNA damage and repair, gene expression and genome replication, and cancer driver genes.

 


David Louis, MD*

David Louis, MD*
Chief, Department of Pathology, Benjamin Castleman Professor of Pathology, Harvard Medical School

Research topics include: glioma, glioblastoma, molecular genetics, molecular pathology and therapeutics.

 


Shyamala Maheswaran, PhD

Shyamala Maheswaran, PhD
Associate Professor of Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: tumorigenesis, breast cancer and cancer genetics.

 


Robert Manguso, PhD

Robert Manguso, PhD
Member of the Faculty of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: cancer immunology, immunotherapy, functional genomics, in vivo screening.

 


Marcela V. Maus, MD, PhD

Marcela V. Maus, MD, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center and Harvard Medical School
Director of Cellular Immunotherapy, Mass General Cancer Center

Research topics include: designing and evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.

 


Andrea L. McClatchey, PhD

Andrea L. McClatchey, PhD
Professor of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School
Patricia and Scott Eston MGH Research Scholar

Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity.

 


David T. Miyamoto, MD, PhD

David T. Miyamoto, MD, PhD
Assistant Professor of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: prostate cancer, biomarkers, circulating tumor cells (CTCs).

 


Raul Mostoslavsky, MD, PhD

Raul Mostoslavsky, MD, PhD
The Laurel Schwartz Professor of Oncology (Medicine), Mass General Cancer Center, Harvard Medical School
Associate Member, The Broad Institute

Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.

 


Mo Motamedi, PhD

Mo Motamedi, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: RNA-mediated epigenetic gene silencing.

 


Christopher Ott, PhD

Christopher Ott, PhD
Assistant Professor, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: cancer epigenetics, chromatin chemical biology, gene expression control in leukemia and lymphoma.

 


Shiv Pillai, MD, PhD

Shiv Pillai, MD, PhD
Professor of Medicine, Harvard Medical School
Associate Geneticist, Center for Cancer Research

Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia.

 


Luca Pinello, PhD

Luca Pinello, PhD
Assistant Professor of Pathology, Massachusetts General Hospital Cancer Center and Harvard Medical School
Faculty, Mass General Pathology

Research topics include: using innovative computational approaches and cutting-edge experimental assays to systematically analyze sources of genetic and epigenetic variation and gene expression variability that underlie human traits and diseases.

 


Esther Rheinbay, PhD

Esther Rheinbay, PhD
Assistant Professor of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: non-coding drivers, FOXA1.

 


Miguel Rivera, MD*

Miguel Rivera, MD*
Assistant Professor of Pathology, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: genomic technologies to identify and characterize pathways implicated in pediatric solid tumors and sarcomas.

 


Dennis Sgroi, MD*

Dennis Sgroi, MD*
Pathologist, Director of Breast Pathology, Massachusetts General Hospital, Professor of Pathology, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: Human Breast Cancer Anti-Hormonal Resistance.

 


Toshiro Shioda, MD, PhD

Toshiro Shioda, MD, PhD
Associate Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: signaling of mammary epithelial cells.

 


David Spriggs, MD

David Spriggs, MD
Member of the Faculty of Medicine at Harvard Medical School

Research topics include: proteins on the ovarian cancer cell surface, CA125, Anti-MUC16, Glycosylation Dependence, Chimeric Antigen Receptor (CAR) T Cells, Galectin 3 Targeting.

 


Shannon Stott, PhD

Shannon Stott, PhD
Assistant Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: Circulating tumor cells; microfludics and control of the cell microenvironment; imaging.

 


Mario Luca Suva, MD, PhD*

Mario Luca Suva, MD, PhD*
Assistant Professor of Pathology, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.

 


David Sweetser, MD, PhD

David Sweetser, MD, PhD
Assistant Professor of Pediatrics, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.

 


David Ting, MD

David Ting, MD
Assistant Professor in Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: Pancreatic ductal adenocarcinoma (PDAC).

 


Shobha Vasudevan, PhD**

Shobha Vasudevan, PhD**
Associate Professor of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School

Research topics include: non-coding RNAs, microRNAs, AU-rich elements, Translation, Cytokines, VEGF, oocytes, cell cycle, quiescence.

 


Alexandra-Chloé Villani, PhD

Alexandra-Chloé Villani, PhD
Assistant Professor of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center

Research topics include: developing and implementing single-cell ‘omics’ strategies and systems immunology approaches to further unravel the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.

 


Lee Zou, PhD*

Lee Zou, PhD*
Professor of Pathology, Harvard Medical School
James & Patricia Poitras Endowed Chair in Cancer Research, Harvard Medical School
Associate Scientific Director, MGH Cancer Center
Jim & Ann Orr MGH Research Scholar

Research topics include: DNA damage response; DNA damage checkpoint; checkpoint signaling; checkpoint activation; genomic instability.

 


* Denotes a joint appointment with the Mass General Molecular Pathology Unit
** Denotes a joint appointment with the Mass General Center for Regenerative Medicine and Technology
*** Denotes a joint recruitment with the Department of Radiation Oncology

† Appointment Process Initiated