The Krantz Family Center for Cancer Research has a dedicated faculty of over 50 independent investigators and 500 students, postdoctoral scientists, research scientists and technologists, committed both to fundamental discovery and to its application in cancer. Research laboratories span from the fundamental biology of cellular proliferation to the molecular analysis of patient-derived clinical specimens, and from the creation of novel drug and immune therapies to the integration of AI-based algorithms for high throughput data analysis.
View our investigators below, and browse faculty by research theme and disease area.
Center for Cancer Research Leadership
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Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Andrea I. McClatchey, PhD Director for Academic Affairs, Krantz Family Center for Cancer Research Poitras Family Endowed Chair in Oncology Professor of Pathology
Nir Hacohen, PhD Director, Center for Cancer Immunology, Krantz Family Center for Cancer Research Director, Center for Cell Circuits, Broad Institute of Harvard and MIT David P. Ryan Endowed Chair in Cancer Research Professor of Medicine
Center for Cancer Research Faculty
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Nabeel Bardeesy, PhD John R. Gallagher III and Katherine A. Gallagher Endowed Chair in Gastrointestinal Cancer Research Associate Professor of Medicine
Research topics include: pancreatic ductal adenocarcinoma.
Priscilla K. Brastianos, MD Terry and Jean de Gunzburg MGH Research Scholar 2021-2026 Associate Professor of Medicine (Neuro-Oncology)
Research topics include: genomic drivers of human brain tumors.
Ryan Corcoran, MD, PhD Director, Tucker Gosnell Center for Gastrointestinal Cancers Mark J. Kusek Endowed Chair in Colorectal Cancer Associate Professor of Medicine
Research topics include: developing new and effective therapies for gastrointestinal cancers.
Shadmehr (Shawn) Demehri, MD, PhD MGH Research Scholar 2023-2028 Associate Professor in Dermatology (Cutaneous Biology Research Center)
Research topics include: role of the immune system in regulating the early stages of cancer development.
Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.
Leif Ellisen, MD, PhD Director, Cancer Center Program in Breast Medical Oncology Nelson Family and Jerry Younger, MD Endowed Chair in Breast Cancer Research Professor of Medicine
Research topics include: P53 and human tumorigenesis; breast cancer.
David Fisher, MD, PhD Director, Cancer Center Melanoma Program Director, Cutaneous Biology Research Center Lancer Professor of Dermatology Edward Wigglesworth Professor and Chair of Dermatology
Research topics include: cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood.
Research topics include: gut microbiota, microbiome, anti-tumor immunity, immunotherapy, immune checkpoint inhibitors
Gad A. Getz, PhD* Director of Bioinformatics, Cancer Center and Pathology Director of Cancer Bioinformatics, Broad Institute of Harvard and MIT Paul Zamecnik, MD Endowed Chair in Oncology Basic Research Professor of Pathology
Research topics include: cancer genome analysis.
Timothy Graubert, MD Director, Cancer Center Program in Hematologic Malignancies Hagler Family Endowed Chair in Hematologic Malignancies Professor of Medicine
Research topics include: molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.
Research topics include: quantitative mass spectrometry-based proteomics to study the cellular pathways that characterize cancer cells.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Nir Hacohen, PhD Director, Center for Cancer Immunology, Krantz Family Center for Cancer Research Director, Center for Cell Circuits, Broad Institute of Harvard and MIT David P. Ryan Endowed Chair in Cancer Research Professor of Medicine
Research topics include: developing new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.
Research topics include: understanding the biological underpinnings of sensitivity and resistance to kinase inhibitor targeted therapies in lung cancers with specific genetic abnormalities (EGFR mutations, ALK translocations, KRAS mutations).
Konrad Hochedlinger, PhD** Gerald and Darlene Jordan Endowed Chair for the Center for Regenerative Medicine Professor of Medicine (Genetics)
Research topics include: pluripotency and nuclear reprogramming.
Hanno Hock, MD, PhD** Brant Carleton Endowed Chair in Acute Myeloid Leukemia Research Assistant Professor of Medicine
Research topics include: transcription factors in blood development and leukemia.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
A. John Iafrate, MD, PhD* Austin L. Vickery, Jr. Professor of Pathology Deputy Chair, Department of Pathology
Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.
Research topics include: understanding the biochemical mechanisms of cancer angiogenesis and cancer metabolism in order to identify and validate new targets for treatment of Renal Cell Carcinoma (RCC).
Research topics include: PD-1, CTLA-4, immunotherapy, tumor microenvironment, organotypic tumor spheroids, 3D culture, microfluidics, cytokines.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Research topics include: using computation as a powerful microscope to study the processes of DNA damage and repair, gene expression and genome replication, and cancer driver genes.
Abner Louissaint, Jr., MD, PhD Aziz and Nur Hamzaogullari Endowed Scholar in Hematologic Malignancies Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: Unraveling biology of lymphomas, especially B-cell lymphomas; defining prognostic markers and therapeutic vulnerabilities via molecular characterization of patient-deived xenograft and in-vitro models of human lymphoma.
Research topics include: tumorigenesis, breast cancer and cancer genetics.
Robert Manguso, PhD Co-Director, Tumor Immunotherapy Discovery Engine, Broad Institute Assistant Professor of Medicine
Research topics include: cancer immunology, immunotherapy, functional genomics, in vivo screening.
Marcela V. Maus, MD, PhD Director, Cancer Center Program in Cellular Immunotherapy Paula J. O’Keeffe Endowed Chair in Thoracic Oncology Associate Professor of Medicine
Research topics include: designing and evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.
Andrea I. McClatchey, PhD Director for Academic Affairs, Krantz Family Center for Cancer Research Poitras Family Endowed Chair in Oncology Professor of Pathology
Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity.
Research topics include: prostate cancer, biomarkers, circulating tumor cells (CTCs).
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Mo Motamedi, PhD James and Patricia Poitras Endowed Chair in Cancer Research Assistant Professor of Medicine
Research topics include: RNA-mediated epigenetic gene silencing.
Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia.
Luca Pinello, PhD Associate Professor in Pathology (Molecular Pathology Unit)
Research topics include: using innovative computational approaches and cutting-edge experimental assays to systematically analyze sources of genetic and epigenetic variation and gene expression variability that underlie human traits and diseases.
Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.
Research topics include: regulation of T cell dysfunction, CD8+ T cells, epigenetic approaches for T cell engineering, immunology, systems biology and epigenomics.
Dennis Sgroi, MD* Executive Vice-Chair of Pathology Professor of Pathology
Research topics include: Human Breast Cancer Anti-Hormonal Resistance.
Research topics include: signaling of mammary epithelial cells.
Shannon Stott, PhD d’Arbeloff MGH Research Scholar 2022-2027 Associate Professor of Medicine
Research topics include: Circulating tumor cells; microfluidics and control of the cell microenvironment; imaging.
Mario Luca Suva, MD, PhD* Vice-Chair of Pathology for Research Director, Molecular Pathology Unit Janet and William Ellery James MGH Research Scholar 2020-2025 Associate Professor of Pathology
Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.
David Sweetser, MD, PhD Chief of Medical Genetics and Metabolism, Department of Pediatrics Leslie Meyer and Lewis Ball Holmes Chair in Genetics and Teratology Assistant Professor of Pediatrics (Pediatrics, Genetics)
Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.
David T. Ting, MD Associate Clinical Director for Innovation, Cancer Center Amin and Zebunisha Juma Endowed Chair in Oncology Associate Professor of Medicine
Research topics include: Pancreatic ductal adenocarcinoma (PDAC).
Research topics include: developing and implementing single-cell ‘omics’ strategies and systems immunology approaches to further unravel the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Research topics include: tumorigenesis, breast cancer and cancer genetics.
Andrea I. McClatchey, PhD Director for Academic Affairs, Krantz Family Center for Cancer Research Poitras Family Endowed Chair in Oncology Professor of Pathology
Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity.
Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.
Leif Ellisen, MD, PhD Director, Cancer Center Program in Breast Medical Oncology Nelson Family and Jerry Younger, MD Endowed Chair in Breast Cancer Research Professor of Medicine
Research topics include: P53 and human tumorigenesis; breast cancer.
Timothy Graubert, MD Director, Cancer Center Program in Hematologic Malignancies Hagler Family Endowed Chair in Hematologic Malignancies Professor of Medicine
Research topics include: molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
Abner Louissaint, Jr., MD, PhD Aziz and Nur Hamzaogullari Endowed Scholar in Hematologic Malignancies Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: Unraveling biology of lymphomas, especially B-cell lymphomas; defining prognostic markers and therapeutic vulnerabilities via molecular characterization of patient-deived xenograft and in-vitro models of human lymphoma.
Research topics include: prostate cancer, biomarkers, circulating tumor cells (CTCs).
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Mo Motamedi, PhD James and Patricia Poitras Endowed Chair in Cancer Research Assistant Professor of Medicine
Research topics include: RNA-mediated epigenetic gene silencing.
Research topics include: cancer epigenetics, chromatin chemical biology, gene expression control in leukemia and lymphoma.
Luca Pinello, PhD Associate Professor in Pathology (Molecular Pathology Unit)
Research topics include: using innovative computational approaches and cutting-edge experimental assays to systematically analyze sources of genetic and epigenetic variation and gene expression variability that underlie human traits and diseases.
Research topics include: regulation of T cell dysfunction, CD8+ T cells, epigenetic approaches for T cell engineering, immunology, systems biology and epigenomics.
Mario Luca Suva, MD, PhD* Vice-Chair of Pathology for Research Director, Molecular Pathology Unit Janet and William Ellery James MGH Research Scholar 2020-2025 Associate Professor of Pathology
Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.
David Sweetser, MD, PhD Chief of Medical Genetics and Metabolism, Department of Pediatrics Leslie Meyer and Lewis Ball Holmes Chair in Genetics and Teratology Assistant Professor of Pediatrics (Pediatrics, Genetics)
Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.
David T. Ting, MD Associate Clinical Director for Innovation, Cancer Center Amin and Zebunisha Juma Endowed Chair in Oncology Associate Professor of Medicine
Research topics include: Pancreatic ductal adenocarcinoma (PDAC).
Shadmehr (Shawn) Demehri, MD, PhD MGH Research Scholar 2023-2028 Associate Professor in Dermatology (Cutaneous Biology Research Center)
Research topics include: role of the immune system in regulating the early stages of cancer development.
David Fisher, MD, PhD Director, Cancer Center Melanoma Program Director, Cutaneous Biology Research Center Lancer Professor of Dermatology Edward Wigglesworth Professor and Chair of Dermatology
Research topics include: cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood.
Research topics include: gut microbiota, microbiome, anti-tumor immunity, immunotherapy, immune checkpoint inhibitors
Nir Hacohen, PhD Director, Center for Cancer Immunology, Krantz Family Center for Cancer Research Director, Center for Cell Circuits, Broad Institute of Harvard and MIT David P. Ryan Endowed Chair in Cancer Research Professor of Medicine
Research topics include: developing new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.
Research topics include: PD-1, CTLA-4, immunotherapy, tumor microenvironment, organotypic tumor spheroids, 3D culture, microfluidics, cytokines.
Robert Manguso, PhD Co-Director, Tumor Immunotherapy Discovery Engine, Broad Institute Assistant Professor of Medicine
Research topics include: cancer immunology, immunotherapy, functional genomics, in vivo screening.
Marcela V. Maus, MD, PhD Director, Cancer Center Program in Cellular Immunotherapy Paula J. O’Keeffe Endowed Chair in Thoracic Oncology Associate Professor of Medicine
Research topics include: designing and evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.
Research topics include: B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia.
Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.
Research topics include: regulation of T cell dysfunction, CD8+ T cells, epigenetic approaches for T cell engineering, immunology, systems biology and epigenomics.
Research topics include: developing and implementing single-cell ‘omics’ strategies and systems immunology approaches to further unravel the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.
Cancer Metabolism
Nabeel Bardeesy, PhD John R. Gallagher III and Katherine A. Gallagher Endowed Chair in Gastrointestinal Cancer Research Associate Professor of Medicine
Research topics include: pancreatic ductal adenocarcinoma.
Research topics include: Transcription factor NRF2, anti-oxidant response, stress signaling.
Leif Ellisen, MD, PhD Director, Cancer Center Program in Breast Medical Oncology Nelson Family and Jerry Younger, MD Endowed Chair in Breast Cancer Research Professor of Medicine
Research topics include: P53 and human tumorigenesis; breast cancer.
Research topics include: understanding the biochemical mechanisms of cancer angiogenesis and cancer metabolism in order to identify and validate new targets for treatment of Renal Cell Carcinoma (RCC).
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Research topics include: using computation as a powerful microscope to study the processes of DNA damage and repair, gene expression and genome replication, and cancer driver genes.
Research topics include: clonal hematopoiesis, leukemia, PPM1D, stem cells.
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Nabeel Bardeesy, PhD John R. Gallagher III and Katherine A. Gallagher Endowed Chair in Gastrointestinal Cancer Research Associate Professor of Medicine
Research topics include: pancreatic ductal adenocarcinoma.
Research topics include: Transcription factor NRF2, anti-oxidant response, stress signaling.
Priscilla K. Brastianos, MD Terry and Jean de Gunzburg MGH Research Scholar 2021-2026 Associate Professor of Medicine (Neuro-Oncology)
Research topics include: genomic drivers of human brain tumors.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Research topics include: tumorigenesis, breast cancer and cancer genetics.
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Mo Motamedi, PhD James and Patricia Poitras Endowed Chair in Cancer Research Assistant Professor of Medicine
Research topics include: RNA-mediated epigenetic gene silencing.
Research topics include: Genomic Instability, Cancer Genomics, Mutational Signatures, Computational Biology, Machine Learning, Cancer Diagnostics, Circulating Tumor DNA, Tumor evolution.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
A. John Iafrate, MD, PhD* Austin L. Vickery, Jr. Professor of Pathology Deputy Chair, Department of Pathology
Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Abner Louissaint, Jr., MD, PhD Aziz and Nur Hamzaogullari Endowed Scholar in Hematologic Malignancies Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: Unraveling biology of lymphomas, especially B-cell lymphomas; defining prognostic markers and therapeutic vulnerabilities via molecular characterization of patient-deived xenograft and in-vitro models of human lymphoma.
Research topics include: prostate cancer, biomarkers, circulating tumor cells (CTCs).
Miguel Rivera, MD* Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024 Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: gene regulation in cancer, chromatin, epigenomics, developmental pathways in cancer.
Dennis Sgroi, MD* Executive Vice-Chair of Pathology Professor of Pathology
Research topics include: Human Breast Cancer Anti-Hormonal Resistance.
Shannon Stott, PhD d’Arbeloff MGH Research Scholar 2022-2027 Associate Professor of Medicine
Research topics include: Circulating tumor cells; microfluidics and control of the cell microenvironment; imaging.
Mario Luca Suva, MD, PhD* Vice-Chair of Pathology for Research Director, Molecular Pathology Unit Janet and William Ellery James MGH Research Scholar 2020-2025 Associate Professor of Pathology
Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.
David T. Ting, MD Associate Clinical Director for Innovation, Cancer Center Amin and Zebunisha Juma Endowed Chair in Oncology Associate Professor of Medicine
Research topics include: Pancreatic ductal adenocarcinoma (PDAC).
Research topics include: Transcription factor NRF2, anti-oxidant response, stress signaling.
Ryan Corcoran, MD, PhD Director, Tucker Gosnell Center for Gastrointestinal Cancers Mark J. Kusek Endowed Chair in Colorectal Cancer Associate Professor of Medicine
Research topics include: developing new and effective therapies for gastrointestinal cancers.
Leif Ellisen, MD, PhD Director, Cancer Center Program in Breast Medical Oncology Nelson Family and Jerry Younger, MD Endowed Chair in Breast Cancer Research Professor of Medicine
Research topics include: P53 and human tumorigenesis; breast cancer.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Research topics include: understanding the biological underpinnings of sensitivity and resistance to kinase inhibitor targeted therapies in lung cancers with specific genetic abnormalities (EGFR mutations, ALK translocations, KRAS mutations).
A. John Iafrate, MD, PhD* Austin L. Vickery, Jr. Professor of Pathology Deputy Chair, Department of Pathology
Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
Research topics include: cancer epigenetics, chromatin chemical biology, gene expression control in leukemia and lymphoma.
RNA Biology
Mo Motamedi, PhD James and Patricia Poitras Endowed Chair in Cancer Research Assistant Professor of Medicine
Research topics include: RNA-mediated epigenetic gene silencing.
Miguel Rivera, MD* Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024 Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: gene regulation in cancer, chromatin, epigenomics, developmental pathways in cancer.
David T. Ting, MD Associate Clinical Director for Innovation, Cancer Center Amin and Zebunisha Juma Endowed Chair in Oncology Associate Professor of Medicine
Research topics include: Pancreatic ductal adenocarcinoma (PDAC).
Research topics include: phenotypic and functional B cell states within tumors, B cell response and cancer immunotherapies.
Gad A. Getz, PhD* Director of Bioinformatics, Cancer Center and Pathology Director of Cancer Bioinformatics, Broad Institute of Harvard and MIT Paul Zamecnik, MD Endowed Chair in Oncology Basic Research Professor of Pathology
Research topics include: Genomic Instability, Cancer Genomics, Mutational Signatures, Computational Biology, Machine Learning, Cancer Diagnostics, Circulating Tumor DNA, Tumor evolution.
Nir Hacohen, PhD Director, Center for Cancer Immunology, Krantz Family Center for Cancer Research Director, Center for Cell Circuits, Broad Institute of Harvard and MIT David P. Ryan Endowed Chair in Cancer Research Professor of Medicine
Research topics include: developing new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
Research topics include: using computation as a powerful microscope to study the processes of DNA damage and repair, gene expression and genome replication, and cancer driver genes.
Mo Motamedi, PhD James and Patricia Poitras Endowed Chair in Cancer Research Assistant Professor of Medicine
Research topics include: RNA-mediated epigenetic gene silencing.
Luca Pinello, PhD Associate Professor in Pathology (Molecular Pathology Unit)
Research topics include: using innovative computational approaches and cutting-edge experimental assays to systematically analyze sources of genetic and epigenetic variation and gene expression variability that underlie human traits and diseases.
Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.
Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.
A. John Iafrate, MD, PhD* Austin L. Vickery, Jr. Professor of Pathology Deputy Chair, Department of Pathology
Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.
Andrea I. McClatchey, PhD Director for Academic Affairs, Krantz Family Center for Cancer Research Poitras Family Endowed Chair in Oncology Professor of Pathology
Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity.
Miguel Rivera, MD* Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024 Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: gene regulation in cancer, chromatin, epigenomics, developmental pathways in cancer.
Shannon Stott, PhD d’Arbeloff MGH Research Scholar 2022-2027 Associate Professor of Medicine
Research topics include: Circulating tumor cells; microfluidics and control of the cell microenvironment; imaging.
Mario Luca Suva, MD, PhD* Vice-Chair of Pathology for Research Director, Molecular Pathology Unit Janet and William Ellery James MGH Research Scholar 2020-2025 Associate Professor of Pathology
Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.
Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.
Leif Ellisen, MD, PhD Director, Cancer Center Program in Breast Medical Oncology Nelson Family and Jerry Younger, MD Endowed Chair in Breast Cancer Research Professor of Medicine
Research topics include: P53 and human tumorigenesis; breast cancer.
Research topics include: gut microbiota, microbiome, anti-tumor immunity, immunotherapy, immune checkpoint inhibitors
Gad A. Getz, PhD* Director of Bioinformatics, Cancer Center and Pathology Director of Cancer Bioinformatics, Broad Institute of Harvard and MIT Paul Zamecnik, MD Endowed Chair in Oncology Basic Research Professor of Pathology
Research topics include: Genomic Instability, Cancer Genomics, Mutational Signatures, Computational Biology, Machine Learning, Cancer Diagnostics, Circulating Tumor DNA, Tumor evolution.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
A. John Iafrate, MD, PhD* Austin L. Vickery, Jr. Professor of Pathology Deputy Chair, Department of Pathology
Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.
Research topics include: Retinoblastoma protein (RB); RB target genes; RB mediated chromatin regulation; cell cycle control; CDK inhibitors.
Dennis Sgroi, MD* Executive Vice-Chair of Pathology Professor of Pathology
Research topics include: Human Breast Cancer Anti-Hormonal Resistance.
Genitourinary Cancers
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Research topics include: understanding the biochemical mechanisms of cancer angiogenesis and cancer metabolism in order to identify and validate new targets for treatment of Renal Cell Carcinoma (RCC).
Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.
Hematologic Malignancies
Gad A. Getz, PhD* Director of Bioinformatics, Cancer Center and Pathology Director of Cancer Bioinformatics, Broad Institute of Harvard and MIT Paul Zamecnik, MD Endowed Chair in Oncology Basic Research Professor of Pathology
Research topics include: cancer genome analysis.
Timothy Graubert, MD Director, Cancer Center Program in Hematologic Malignancies Hagler Family Endowed Chair in Hematologic Malignancies Professor of Medicine
Research topics include: molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.
Hanno Hock, MD, PhD** Brant Carleton Endowed Chair in Acute Myeloid Leukemia Research Assistant Professor of Medicine
Research topics include: transcription factors in blood development and leukemia.
Research topics include: targeted protein degradation, chemical biology, functional genomics, cellular immunotherapy.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Abner Louissaint, Jr., MD, PhD Aziz and Nur Hamzaogullari Endowed Scholar in Hematologic Malignancies Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: Unraveling biology of lymphomas, especially B-cell lymphomas; defining prognostic markers and therapeutic vulnerabilities via molecular characterization of patient-deived xenograft and in-vitro models of human lymphoma.
Marcela V. Maus, MD, PhD Director, Cancer Center Program in Cellular Immunotherapy Paula J. O’Keeffe Endowed Chair in Thoracic Oncology Associate Professor of Medicine
Research topics include: designing and evaluating next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.
Research topics include: developing and implementing single-cell ‘omics’ strategies and systems immunology approaches to further unravel the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.
Liver, Pancreatic and Gastrointestinal Cancers
Nabeel Bardeesy, PhD John R. Gallagher III and Katherine A. Gallagher Endowed Chair in Gastrointestinal Cancer Research Associate Professor of Medicine
Research topics include: pancreatic ductal adenocarcinoma.
Ryan Corcoran, MD, PhD Director, Tucker Gosnell Center for Gastrointestinal Cancers Mark J. Kusek Endowed Chair in Colorectal Cancer Associate Professor of Medicine
Research topics include: developing new and effective therapies for gastrointestinal cancers.
Konrad Hochedlinger, PhD** Gerald and Darlene Jordan Endowed Chair for the Center for Regenerative Medicine Professor of Medicine (Genetics)
Research topics include: pluripotency and nuclear reprogramming.
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
Andrea I. McClatchey, PhD Director for Academic Affairs, Krantz Family Center for Cancer Research Poitras Family Endowed Chair in Oncology Professor of Pathology
Research topics include: neurofibromatosis type 2; epidermal growth factor receptor (EGFR); cortical cytoskeleton; Ezrin, radixin, moesin (ERM proteins); polarity.
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Mo Motamedi, PhD James and Patricia Poitras Endowed Chair in Cancer Research Assistant Professor of Medicine
Research topics include: RNA-mediated epigenetic gene silencing.
David T. Ting, MD Associate Clinical Director for Innovation, Cancer Center Amin and Zebunisha Juma Endowed Chair in Oncology Associate Professor of Medicine
Research topics include: Pancreatic ductal adenocarcinoma (PDAC).
Research topics include: quantitative mass spectrometry-based proteomics to study the cellular pathways that characterize cancer cells.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Research topics include: understanding the biological underpinnings of sensitivity and resistance to kinase inhibitor targeted therapies in lung cancers with specific genetic abnormalities (EGFR mutations, ALK translocations, KRAS mutations).
Research topics include: Spatial and systems oncology; cancer neuroscience; therapeutic resistance; single-cell omics; cell-cell interactions; cell state plasticity; computational biology.
A. John Iafrate, MD, PhD* Austin L. Vickery, Jr. Professor of Pathology Deputy Chair, Department of Pathology
Research topics include: bringing new genetic technologies to cancer diagnostics and applying them to improve the practice of pathology.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.
Shadmehr (Shawn) Demehri, MD, PhD MGH Research Scholar 2023-2028 Associate Professor in Dermatology (Cutaneous Biology Research Center)
Research topics include: role of the immune system in regulating the early stages of cancer development.
David Fisher, MD, PhD Director, Cancer Center Melanoma Program Director, Cutaneous Biology Research Center Lancer Professor of Dermatology Edward Wigglesworth Professor and Chair of Dermatology
Research topics include: cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood.
Research topics include: Genomic Instability, Cancer Genomics, Mutational Signatures, Computational Biology, Machine Learning, Cancer Diagnostics, Circulating Tumor DNA, Tumor evolution.
Daniel A. Haber, MD, PhD Director, Krantz Family Center for Cancer Research Director, Mass General Cancer Center Kurt J. Isselbacher Professor of Oncology (Medicine) Investigator, Howard Hughes Medical Institute
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer.
Nir Hacohen, PhD Director, Center for Cancer Immunology, Krantz Family Center for Cancer Research Director, Center for Cell Circuits, Broad Institute of Harvard and MIT David P. Ryan Endowed Chair in Cancer Research Professor of Medicine
Research topics include: developing new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.
Research topics include: tumorigenesis, breast cancer and cancer genetics.
Robert Manguso, PhD Co-Director, Tumor Immunotherapy Discovery Engine, Broad Institute Assistant Professor of Medicine
Research topics include: cancer immunology, immunotherapy, functional genomics, in vivo screening.
Raul Mostoslavsky, MD, PhD Scientific Director, Krantz Family Center for Cancer Research Laurel Schwartz Professor in Medicine in the Field of Oncology Professor of Medicine
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair.
Research topics include: Immuno-oncology, single-cell multi-omics, systems-biology approach for the identification of therapy resistance mechanisms, melanoma, HNSCC, NSCLC.
Research topics include: regulation of T cell dysfunction, CD8+ T cells, epigenetic approaches for T cell engineering, immunology, systems biology and epigenomics.
Mario Luca Suva, MD, PhD* Vice-Chair of Pathology for Research Director, Molecular Pathology Unit Janet and William Ellery James MGH Research Scholar 2020-2025 Associate Professor of Pathology
Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.
David Sweetser, MD, PhD Chief of Medical Genetics and Metabolism, Department of Pediatrics Leslie Meyer and Lewis Ball Holmes Chair in Genetics and Teratology Assistant Professor of Pediatrics (Pediatrics, Genetics)
Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.
Research topics include: DNA damage response; Replication stress; Ubiquitination; Quantitative proteomics.
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Miguel Rivera, MD* Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024 Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: gene regulation in cancer, chromatin, epigenomics, developmental pathways in cancer.
David Sweetser, MD, PhD Chief of Medical Genetics and Metabolism, Department of Pediatrics Leslie Meyer and Lewis Ball Holmes Chair in Genetics and Teratology Assistant Professor of Pediatrics (Pediatrics, Genetics)
Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell, targeted therapy.
Sarcoma
David Langenau, PhD* Atul K. Bhan, MBBS, MD, Endowed Chair in Experimental Pathology Professor of Pathology (Molecular Pathology Unit)
Research topics include: uncovering mechanisms that drive relapse in pediatric tumors to help identify new therapeutic drug targets to treat relapse disease.
Miguel Rivera, MD* Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024 Associate Professor of Pathology (Molecular Pathology Unit)
Research topics include: gene regulation in cancer, chromatin, epigenomics, developmental pathways in cancer.
* Denotes a joint appointment with the Mass General Molecular Pathology Unit ** Denotes a joint appointment with the Mass General Center for Regenerative Medicine and Technology *** Denotes a joint recruitment with the Department of Radiation Oncology
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The newly named Krantz Family Center for Cancer Research will empower Mass General Cancer Center researchers to tackle the major unsolved challenges in oncology.