Search Cancer Clinical Trials

Mass General Brigham Cancer Institute offers patients access to a wide variety of clinical trials of promising new therapies. Use the search tool to find open protocols for your type of cancer.
11 results
  • Head and Neck Cancer, Sarcoma, Pancreatic Cancer, Ovarian Cancer, Lung Cancer, Liver Cancer, Breast Cancer, Thyroid Cancer, Kidney Cancer

23-301          Phase I

A First-in-Human, Open-label, Multicenter, Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PYX-201 in Participants with Advanced Solid Tumors

  • Liver Cancer

24-265          Phase I

A Multicenter, Open-label, First-in-Human Study of TYRA-200 in Advanced Intrahepatic Cholangiocarcinoma and Other Solid Tumors with Activating FGFR2 Gene Alterations (SURF-201)

  • Liver Cancer

25-145          Phase I

A Multicenter, Open-label, First-in-Human Study of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors with Activating FGF/FGFR pathway aberrations (SURF-431)

  • Gastric (Stomach) Cancer, Sarcoma, Bladder Cancer, Endometrial Cancer, Esophageal Cancer, Liver Cancer, Pancreatic Cancer

20-544          Phase II

A Phase 1/2 Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of PC14586 in Patients with Advanced Solid Tumors Harboring a p53 Y220C Mutation

  • Endometrial Cancer, Liver Cancer, Bladder Cancer, Breast Cancer

24-666          Phase II

A Phase 1/2 Study of a Selective FGFR2/3 Inhibitor, CGT4859, in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors Harboring FGFR2 and/or FGFR3 Genetic Alterations

  • Liver Cancer

24-700          Phase I

A Phase I Dose Escalation and Cohort Expansion Study of TSR-022, an Anti-TIM-3 Monoclonal Antibody, In Patients with Advanced Sold Tumors (AMBER)

  • Melanoma, Pancreatic Cancer, Breast Cancer, Endometrial Cancer, Kidney Cancer, Lung Cancer, Liver Cancer

25-587          Phase II

A Phase I/II, open-label, adaptive two-part trial to evaluate the safety, efficacy, optimal dose and pharmacokinetics of BNT326 as monotherapy and in combination with cancer immunotherapies in participants with advanced solid tumors

  • Gallbladder and Bile Duct Cancers, Liver Cancer

21-725          Phase I

A Phase Ia/Ib Study of the Combination of the FGFR inhibitor Pemigatinib and the EGFR inhibitor Afatinib in Advanced Refractory Advanced Solid Tumors

  • Melanoma, Lung Cancer, Liver Cancer, Head and Neck Cancer, Endometrial Cancer, Bladder Cancer, Colorectal Cancer

24-203          Phase I

An Open-Label Study of GV20-0251 in Patients with Advanced and/or Refractory Solid Tumor Malignancies

  • Liver Cancer

23-394          Phase III

Phase 2/3 Randomized, Controlled Study of CTX-009 in Combination with Paclitaxel versus Paclitaxel Alone in Adult Patients with Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers who have received One Prior Systemic Chemotherapy Regimen

Showing 1 - 10 of 11 results