Studying mice and fruit flies, researchers found that the enzyme intestinal alkaline phosphatase (IAP) helped prevent intestinal permeability and gut-derived systemic inflammation, resulting in less frailty and extended life span.
Departments, Centers, & Programs:
15 Parkman Street
Boston, MA 02114-3117
- MD, Tulane University School of Medicine
- Residency, Beth Israel Deaconess Medical Center
- Fellowship, Beth Israel Deaconess Medical Center
American Board Certifications
- Surgery, American Board of Surgery
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The Laboratory of Gastrointestinal Epithelial Biology
Principal Investigator: Richard A. Hodin, MD
The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota..
The small intestine is lined by a simple columnar epithelium in which pluripotent, proliferating crypt cells (stem cells) give rise to four distinct lineages of differentiated cells, including enterocytes (95%), goblet, and enteroendocrine cells on the villi, and paneth cells at the crypt base. The various projects ongoing in the lab relate to understanding the differentiation process in the contexts of (1) normal development, (2) homeostasis within the adult, (3) pathological conditions such as starvation, cancer, and inflammatory bowel disease. Presently, we are focused on defining the mechanisms that govern gut mucosal defense and the interplay between the host and the intestinal microflora.
Over 150 publications - please see PubMed list