About Santiago Lozano-Calderon, MD, PhD

Dr. Santiago Lozano specializes in the evaluation and treatment of primary benign and malignant tumors of bone and soft tissue, as well as metastatic bone disease. His practice involves clinical research evaluating treatment and outcomes in oncology patients.

Dr. Lozano is a board-certified orthopaedic oncology surgeon. He earned his MD from Pontificia Universidad Javeriana Medical School in Bogota, Colombia.

Following his MD, he earned his PhD from the University of Amsterdam in the Netherlands. He conducted his PhD thesis research with Dr. Jesse Jupiter and Dr. David Ring at Massachusetts General Hospital. Dr. Lozano then completed his Orthopaedic Surgery Residency at New York Medical College in Valhalla, New York. He also completed a fellowship in Orthopaedic Oncology at Massachusetts General Hospital.

Clinical Interests:




Orthopaedic Oncology Service | Centers for Sarcoma & Chordoma
55 Fruit Street
Yawkey Center for Outpatient Care
Suite 3B
Boston, MA 02114
Phone: 617-643-4947

Medical Education

  • MD, Pontificia Universidad Javeriana Medical School
  • Residency, New York Medical College
  • Fellowship, Massachusetts General Hospital*****

American Board Certifications

  • Orthopaedic Surgery, American Board of Orthopaedic Surgery

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Dr. Lozano has a strong interest in clinical research in orthopaedic oncology. His academic practice involves multiple clinical studies evaluating particular neoplastic problems of osseous and connective tissue nature. His focus of research includes clinical outcomes after reconstructive oncologic surgery in the upper and lower extremities, oncologic problems in the upper extremity and functional outcomes after surgical treatment in patients with primary sarcomas of bone and soft-tissue, as well as metastatic bone disease.

In the video below, he discusses the latest innovations in treating bone cancer using patient profiling to develop more targeted treatment plans. You can read more about Dr. Lozano's research on Mass General's Advances in Motion website


  • Recent publications:

    • Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Investigators, Ghert M, Schneider P, Guyatt G, Thabane L, V?lez R, O'Shea T, Randall RL, Turcotte R, Wilson D, Wunder JS, Baptista AM, Cheng EY, Doung YC, Ferguson PC, Giglio V, Hayden J, Heels-Ansdell D, Khan SA, Sampath Kumar V, McKay P, Miller B, van de Sande M, Zum?rraga JP, Bhandari M. Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial. JAMA Oncol. 2022 Jan 6.
    • Melnic CM, Cohen-Levy WB, Lozano-Calderon SA, Heng M. Treatment of Severe Acetabular Bone Loss Using a Tantalum Acetabular Shell and a Cemented Monoblock Dual Mobility Acetabular Cup. J Am Acad Orthop Surg. 2021 Dec 17.
    • Groot OQ, Lans A, Twining PK, Bongers MER, Kapoor ND, Verlaan JJ, Newman ET, Raskin KA, Lozano-Calderon SA, Janssen SJ, Schwab JH. Clinical Outcome Differences in the Treatment of Impending Versus Completed Pathological Long-Bone Fractures. J Bone Joint Surg Am. 2021 Nov 30.
    • Fourman MS, Ramsey DC, Newman ET, Schwab JH, Chen YL, Hung YP, Chebib I, Deshpande V, Nielsen GP, DeLaney TF, Mullen JT, Raskin KA, Lozano Calder?n SA. Assessing the Safety and Utility of Wound VAC Temporization of the Sarcoma or Benign Aggressive Tumor Bed Until Final Margins Are Achieved. Ann Surg Oncol. 2021 Nov 9. doi: 10.1245/s10434-021-11023-9.
    • Kelly SP, Ramkumar DB, Lozano-Calderon SA, Newman ET, Raskin KA, Chebib I, Schwab JH, Peacock ZS. Sclerostin Immunohistochemical Staining in Aggressive Maxillofacial Giant Cell Lesions: Initial Results and Potential Therapeutic Target. J Craniofac Surg. 2021 Nov 9.
    • Lunn K, Hoftiezer Y, Lans J, van der Heijden B, Chen N, Lozano-Calder?n SA. Joint-sparing versus nonjoint-sparing reconstruction of the radius following oncologic resection: A systematic review. J Surg Oncol. 2021 Dec;124(8):1523-1535.

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