Explore the Prostate Cancer Genetics Program

The Prostate Cancer Genetics Program helps to identify and provide comprehensive, coordinated medical care for families that have a hereditary predisposition to prostate cancer. Under the direction of Matthew Smith, MD, PhD, and Keyan Salari, MD, PhD, our program includes specialists in both uro-oncology and genetics.

Patients with pathogenic variants in hereditary prostate cancer genes are managed comprehensively with our team of physicians and genetic counselors. We also provide risk assessment for patients interested in an evaluation for hereditary prostate cancer. During the initial genetics consultation, family history is carefully reviewed. If your personal or family history suggests a possible genetic risk, we will discuss the option of genetic testing.

Should You Consider Genetic Counseling?

Our program is appropriate for any individual that has a pathogenic variant in a prostate cancer predisposition gene. It may also be right for you if you have a personal or family history of one or more of the following:

  • Metastatic prostate cancer
  • Prostate cancer diagnosed with Gleason score of 7 or greater
  • Prostate cancer in three or more people on one side (maternal or paternal) of the family
  • Prostate cancer in an individual of Ashkenazi Jewish descent
  • Personal history of prostate cancer with family history of breast, prostate, colon, ovarian, pancreatic, or uterine cancer.

Hereditary Prostate Cancer Diseases

The syndromes most commonly discussed with patients in our program include:

View our library of fact sheets about inherited cancer risk and genetic testing.


Patient Education and Resources

Genetic Testing Fact Sheets

Genetic Testing Fact Sheets

View our library of genetic testing fact sheets.

Genetic Testing FAQs

Genetic Testing FAQs

Answers to genetic testing FAQs, by our team of certified genetic counselors.

Mind Body Program

Mind Body Program

Learn about the Mind Body Program for Individuals with Hereditary Cancer Syndromes.

Prostate Cancer Treatment Program

Prostate Cancer Treatment Program

Learn about the Cancer Center's Prostate Cancer Treatment Program.

Center for Cancer Risk Assessment

Center for Cancer Risk Assessment

Provides genetic counseling and testing for those who may be at risk of hereditary cancer.