Prostate Cancer Genetics Program

The Prostate Cancer Genetics Program helps to identify and provide comprehensive, coordinated medical care for families that have a hereditary predisposition to prostate cancer. Under the direction of Matthew Smith, MD, PhD, and Keyan Salari, MD, PhD, our program includes specialists in both uro-oncology and genetics.

Patients with pathogenic variants in hereditary prostate cancer genes are managed comprehensively with our team of physicians and genetic counselors. We also provide risk assessment for patients interested in an evaluation for hereditary prostate cancer. During the initial genetics consultation, family history is carefully reviewed. If your personal or family history suggests a possible genetic risk, we will discuss the option of genetic testing.

Should You Consider Genetic Counseling?

Our program is appropriate for any individual that has a pathogenic variant in a prostate cancer predisposition gene. It may also be right for you if you have a personal or family history of one or more of the following:

• Metastatic prostate cancer
• Prostate cancer diagnosed with Gleason score of 7 or greater
• Prostate cancer in three or more people on one side (maternal or paternal) of the family
• Prostate cancer in an individual of Ashkenazi Jewish descent
• Personal history of prostate cancer with family history of breast, prostate, colon, ovarian, pancreatic, or uterine cancer.

Hereditary Prostate Cancer Diseases

The syndromes most commonly discussed with patients in our program include:

• Hereditary breast and ovarian cancer syndrome (BRCA1/2 information)
• HOXB13 gene mutation
• Lynch syndrome

View our library of fact sheets about inherited cancer risk and genetic testing.