How does lung cancer treatment vary by stage?

Lung cancer, like other cancers, is divided into "stages" based on the size, number, and spread of tumors. If you're diagnosed with lung cancer, the stage will give you information about how far the condition has progressed and the best lung cancer treatment for you.

Our approach to lung cancer care

At the Mass General Brigham Cancer Institute, you receive care from an experienced team dedicated to diagnosing and treating lung cancer. Together, they develop a personalized treatment plan based on the type and stage of cancer, genetic and molecular findings, and your overall health and goals.

Stages of non-small cell lung cancer (NSCLC)

When diagnosing non-small cell lung cancer, the most common kind of lung cancer, doctors use four stages:

  • Stage 1: The cancer is small and isolated to a single portion of the lung.
  • Stage 2: The cancer is larger but still contained within one lung, though it may have spread to lymph nodes in the lung, or there may be multiple tumors in the same lobe of the lung.
  • Stage 3: The cancer may be larger and affecting regional lymph nodes within the chest but hasn’t traveled outside of the same lung, or there may be multiple tumors across different lobes of the same lung.
  • Stage 4: The cancer has spread to distant structures like the other lung, fluid around the organs, or distant organs. Cancers in this stage may also be called metastatic cancer.

Some classifications also include a fifth stage, called "Stage 0," in which the cancer is contained within the top lining of the lung and hasn't yet spread.

Diagnosing small cell lung cancer uses a two-stage system:

  • Limited: The cancer is on one side of the chest. It may be limited to one lung or have spread to nearby lymph nodes.
  • Extensive: The cancer has spread to the other lung or other parts of the body, including distant organs like the heart or brain.

Lung cancer treatments by stage (NSCLC and SCLC)

The best treatments for lung cancer depend on the current stage of the cancer. Early-stage lung cancer treatments may be able to cure lung cancer.

As the disease progresses, the odds of a cure decrease, so advanced-stage lung cancer treatments usually focus on improving quality of life.

Stage 1 lung cancer treatment

Stage 1 lung cancer treatments focus on trying to remove the cancer with surgery or radiation therapy.

Small cell lung cancer (SCLC) is the exception. It's rarer than non-small cell lung cancer (NSCLC)—only about 15% of lung cancer cases are SCLC—but usually can't be treated surgically.

If you're diagnosed with SCLC, your treatment plan will probably include chemotherapy and radiation.

Stage 2 lung cancer treatment

Stage 2 lung cancer is typically treated with:

Learn more about the differences between SCLC and NSCLC.

Stage 3 lung cancer treatment

In this stage, the best lung cancer treatment will vary depending on the location, quantity, and size of the tumors. You may receive a mix of:

  • Radiation
  • Chemotherapy
  • Immunotherapy

Stage 3 SCLC will usually be treated with:

  • Chemotherapy
  • Radiation

Stage 4 lung cancer treatment

Stage 4 lung cancer treatment options are mostly palliative, meaning that they focus on reducing symptoms and improving quality of life. The options for SCLC and NSCLC are similar and include:

  • Palliative care
  • Chemotherapy
  • Radiotherapy
  • Immunotherapy

FAQs about lung cancer treatment by stage

At what stage is lung cancer most curable?

While each individual case is different, early-stage cancer can mean there is a wider array of treatment options available. Regardless of the stage, your oncologist will help tailor the best treatment plan for you.

Can lung cancer be cured at stage 4?

In general, stage 4 cancer isn't curable. Treatment plans for stage 4 patients focus on reducing symptoms and improving quality of life but are unlikely to lead to a permanent cure.

Does chemotherapy work on stage 4 lung cancer?

Chemotherapy can provide benefits for stage 4 cancer patients, such as keeping symptoms down and slowing the development of the disease, but it probably won't cure advanced-stage cancer.

Learn more about chemotherapy for lung cancer.

How long is a chemotherapy session for lung cancer?

Chemotherapy for non-small cell lung cancer (NSCLC) is usually given in cycles of three to four weeks, including the treatment time and a rest period. The number of cycles depends on the stage of your cancer. Advanced lung cancer treatment options usually include more cycles of chemotherapy.

Small cell lung cancer is treated the same way—cycles of three to four weeks, including a rest period—but may include more cycles than NSCLC in the early stages due to the more aggressive nature of SCLC.

 

At what stage is lung cancer usually diagnosed?

Lung cancer is most often diagnosed in stages 3 and 4. Learn more about how lung cancer is diagnosed.