Mandinova Lab

Overview

In the Mandinova lab we use the epidermis as a model system to study adult stem cells in health and disease. The questions we ask are: How is homeostatic stem cell renewal regulated and how is it balanced with commitment to differentiation to ensure tissue integrity? How does the epidermis withstand and repair frequent injuries and insults? How are genomically damaged stem cells guarded and what permits, in rare cases, aberrant clonal expansion and transformation into benign and malignant lesions? To find our answers, we focus extensively on posttranscriptional regulation of gene expression and its interplay with cellular metabolism. We reason that this approach offers realistic opportunities for therapeutic intervention and identification of “druggable” targets.

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