Cutaneous Biology Research Center
The Cutaneous Biology Research Center (CBRC) at Massachusetts General Hospital is a multidisciplinary team of basic and physician scientists working together to conduct innovative fundamental and translational research on cutaneous structure, development, function and pathophysiology.
A listing of the Principal Investigators at the Cutaneous Biology Research Center at Massachusetts General Hospital.
David E. Fisher, MD, PhD
Dr. Fisher’s lab studies cell death and proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood. His lab aims to understand critical modes of cell homeostasis with the goal of preventing melanoma and other human cancers and developing targeted molecular therapies.
Shawn Demehri, MD, PhD
Dr. Demehri’s lab aims to determine the role of the immune system in regulating the early stages of cancer development to harness its anti-tumor potential for cancer treatment and prevention.
Gian Paolo Dotto, MD, PhD
Dr. Dotto’s laboratory focuses on determinants of pre-malignant to malignant tumor conversion and field cancerization, a condition of major clinical significance consisting of multifocal and recurrent tumors associated with widespread changes (cancer fields) of surrounding normal tissues.
Katia Georgopoulos, PhD
Dr. Georgopoulos Lab's major goal is to understand how multipotent progenitors of the hematopoietic and epithelial systems utilize diverse programs in gene expression to achieve distinct fates in cellular differentiation.
Ethan A. Lerner, MD, PhD
Dr. Lerner’s Lab studies itch. His lab’s goal is to understand the mechanisms that underlie the sensation of itch to develop effective anti-itch therapies.
Anna Mandinova, MD, PhD
The Mandinova Laboratory uses genetic and chemical biology approaches in models of epidermal growth and differentiation to understand molecular pathways involved in stem cell decisions and tumor development in the skin.
Dieter Manstein, MD, PhD
The Manstein lab conducts basic and clinical research related to novel, energy-based procedures in dermatology.
Alexander Marneros, MD, PhD
Dr. Marneros’ Lab is interested in the molecular and cellular mechanisms that drive pathological angiogenesis. His lab’s work focuses on growth factors and inflammatory cells that regulate abnormal blood vessel formation in inflammation, wound healing, and age-related macular degeneration.
Bruce A. Morgan, PhD
The goal of the Morgan Lab is to understand the molecular genetics of appendage formation in vertebrates.
Jin Mo Park, PhD
The Park lab is investigating cell signaling and gene regulatory mechanisms underlying immunity and tissue homeostasis with the aim of developing new clinical strategies for the treatment of inflammatory diseases and cancer.
Jian Shu, PhD
We are passionate about understanding the players and interactions in complex biological ecosystems at single-cell resolution and methods to reprogram and engineer cellular and molecular circuits.
Kristin White, PhD
The overall goal of the White Lab is to understand the regulation, execution, and role of apoptosis in the context of animal development, using the powerful genetic and molecular techniques available in Drosophila.
Xu Wu, PhD
The Wu Lab focuses on studying cellular functions (self-renewal, differentiation, proliferation, and chromatin remodeling) and developmental signaling pathways using chemical and genomic tools.
Bin Zheng, PhD
The Zheng Laboratory’s research focuses on metabolic signaling in melanoma. The lab is interested in understanding how rewired metabolism in cancer cells is coordinated with other hallmarks of cancer to influence caner initiation, promotion and progression.