Explore This Lab


The focus of the Manstein Lab is on the investigation and development of novel methods and devices to solve important clinical problems in dermatology. Dr. Manstein’s dual training in laser physics and clinical dermatology as well as the diverse background and training of lab members greatly facilitates contributing to innovative medical device solutions in dermatology.


View a complete list of Manstein Lab publications at PubMed

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Kepp, T., Droigk, C., Casper, M., Evers, M., Hüttman, G., Salma, N., Manstein, D., Heinrich, M.P., Handels, H. Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks. Biomedical Optics Express. 2019 Jun 21;10(7):3484-3496. doi: 10.1364/BOE.10.003484. eCollection 2019 Jul 1.

Casper, M., Schulz-Hildebrandt, H., Evers, M., Birngruber, R., Manstein, D., Hüttman, G. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography. Journal of Biomedical Optics. 2019 Apr;2494):1-11. doi: 10.1117/1.JBO.24.4.046005.

Evers, M., Salma, N., Osseiran, S., Casper, M., Birngruber, R., Evans, C.L., Manstein, D. Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM. Scientific Reports. 2018 Jun 8;8(1):8757. doi: 10.1038/s41598-018-27093-x.

Evers, M., Ha, L., Casper, M., Welford, D., Kositratna, G., Birngruber, R., Manstein, D. Assessment of skin lesions produced by focused, tunable, mid-infrared chalcogenide laser radiation. Lasers in Surgery and Medicine. 2018 Sep;50(9):961-972. doi: 10.1002/lsm.22935. Epub 2018 May 25.

Sajjadi, A.Y., Manstein, D., Carp, S.A. Measuring Temperature Induced Phase Change Kinetics in Subcutaneous Adipose Tissues Using Near Infrared Spectroscopy, MR Imaging, and Spectroscopy and OCT. Scientific Reports. 2017 Dec 19;7(1):17786. doi: 10.1038/s41598-017-18145-9.

Kawakubo, M., Cunningham, T.J., Demehri, S., Manstein, D. Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity. Scientific Reports. 2017 oct 6;7(1):12751. doi: 10.1038/s441598-017-13095-8.

Kawakubo, M., Demehri, S., Manstein, D. Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response. PloS One. 2017 Sep 18;12(9):e0184852. doi: 10.1371/journal.pone.0184852. eCollection 2017.

Trousil, S., Chen, S., Mu, C., Shaw, F.M., Yao, Z., Ran, Y., Shakuntala, T., Merghoub, T., Manstein, D., Rosen, N., Cantley, L.C., Zippin, J.H., Zheng, B. Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma. The Journal of Investigative Dermatology. 2017 May;137(5):1135-1143. doi: 10.1016/j.jid.2017.01.013. Epub 2017 Jan 28.

Manstein, D. Special dermatology/plastic surgery issue 2017. Lasers in Surgery and Medicine. 2017 Jan;49(1):3-6. doi: 10.1002/lsm.22623. Epub 2017 Jan 27.

Kositratna, G., Hibert, M.L., Jaspan, M., Welford, D., Manstein, D. Effects of deviation from focal plane on lesion geometry for ablative fractional photothermolysis. Lasers in Surgery and Medicine. 2016 Jul;48(5):555-61. doi: 10.1002/lsm.22481. Epub 2016 Feb 4.

Kositratna, G., Evers, M., Sajjadi, A., Manstein, D. Rapid fibrin plug formation within cutaneous ablative fractional CO2 laser lesions. Lasers in Surgery and Medicine. 2016 Feb;48(2):125-32. doi: 10.1002/lsm.22412. Epub 2015 Sep 21.

Erlendsson, A.M., Anderson, R.R., Manstein, D., Waibel, J.S. Developing technology: ablative fractional lasers enhance topical drug delivery. Dermatological Surgery: official publication for American Society for Dermatological Surgery [et al.]. 2014 Dec;40 Suppl 12:S142-6. doi: 10.1097/DSS.0000000000000207.

Chen, X., Kositratna, G., Zhou, C., Manstein, D., Wu, M.X. Micro-fractional epidermal powder delivery for improved skin vaccination. Journal of Controlled Release: official journal of the Controlled Release Society. 2014 Oct 28;192:310-6. doi: 10.1016/j.jconrel.2014.08.006. Epub 2014 Aug 15.

Mallidi, S., Anbil, S., Lee, S., Manstein, D., Elrington, S., Kositratna, G., Schoenfeld, D., Pogue, B., Davis, S.J., Hasan, T. Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema. Journal of Biomedical Optics. 2014 Feb;19(2):028001. doi: 10.1117/1.JBO.19.2.028001.

Zelickson, B., Egbert, B.M., Preciado, J., Allison, J., Springer, K., Rhoades, R.W., Manstein, D. Cryolipolysis for noninvasive fat cell destruction: initial results from a pig model. Dermatological Surgery: official publication for American Society for Dermatological Surgery [et al.]. 2009 Oct;35(10):1462-70. doi: 10.1111/j.1524-4725.2009.01259.x. Epub 2009 Jul 13.

Manstein, D., Laubach, H., Watanabe, K., Farinelli, W., Zurakowski, D., Anderson, R.R. Selective cryolysis: a novel method of non-invasive fat removal. Lasers in Surgery and Medicine. 2008 Nov;40(9):595-604. doi: 10.1002/lsm.20719.

Laubach, H.J., Tannous, Z., Anderson, R.R., Manstein, D. Skin responses to fractional photothermolysis. Lasers in Surgery and Medicine. 2006 Feb;38(2):142-9. doi: 10.1002/lsm.20254.

Manstein, D., Herron, G.S., Sink, R.K., Tanner, H., Anderson, R.R. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers in Surgery and Medicine. 2004;34(5):426-38. doi: 10.1002/lsm.20048.