About Florence Lai, MD

Clinical Interests:




McLean Hospital
115 Mill St.
Belmont, MA 02478
Phone: 617-855-2354
Fax: 617-855-3731

Mass General for Children: Pediatric Neurology
55 Fruit St.
Yawkey Center for Outpatient Care
Suite 6B
Boston, MA 02114
Phone: 617-724-6400
Fax: 617-724-7860

Medical Education

  • MD, University of Pennsylvania
  • Residency, Boston Medical Center
  • Residency, Bronx Municipal Hospital Center

American Board Certifications

  • Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology
  • Pediatrics, American Board of Pediatrics

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


1984-1989. NICHD. Optimizing selective attention in mental retardation: project 6 "Functional decline in Down syndrome individuals over age 40 in a longitudinal study".  Clinical collaborator. Marcel Kinsbourne, PI

1992-1993. Alzheimer's Association/Thomas . Klutznick Co. pilot research grant." Neurologic and neuropsychologic evaluations in pre-demented Down syndrome individuals".  Principal investigator.

1995-1994. NIA. Pilot PI for " Down syndrome pilot studies: Alzheimer's disease diagnosis in Down syndrome."
LEAD Award "Proteolysis in Alzheimer's disease pathogenesis.  RA Nixon, PI

1998-2003. Consultant for NIA study, "Epidemiology of menopause and dementia in Down syndrome" N. Schupf, PI

1999-2010.  Site PI for NIA/NICHD/National Institute of Complementary and Alternative Medicine study "A multicenter Vitamin E Trial in aging persons with Down syndrome"  Project directors: AJ Dalton, PS Aisen, MC Sano


  • Lai F, Williams RS.  A prospective study of Alzheimer disease in Down syndrome. Arch Neurol 1989;46(8):849-853.

    Lai F
    Clinicopathologic features of Alzheimer disease in Down syndrome.  Progress in Clinical Biological Research 1992; 379:15-34.

    Hyman BT, West HL, Rebeck GW, Lai F, Mann DMA.  Neuropathological changes in Down syndrome hippocampal formation: effect of age and apolipoprotein E genotype. Arch Neurol 1995; 52:373-378.

    Alyward EH, Burt DB, Thorpe LU, Lai F, Dalton AJ. Diagnosis of dementia in individuals with intellectual disability. J Intellect Disab Res 1997; 41:152-164.

    Lai F, Kammann E, Rebeck GW, Anderson AJ, Chen Y, Nixon RA.  ApoE and gender effects on Alzheimer disease in 100 adults with Down syndrome.  Neurology 1999; 53:331-336.

    Schupf N, Pang D, Patel, S Liverman, Schubert R, Lai F, Kline Jk, Stern Y, Ferin M, Tycko B, Maeux R.  Onset of dementia is associated with age at menopause in women with Down syndrome. Annals of Neurology 2003; 54:433-438.

    Sano M, Aisen PS, Dalton AJ, Andrews HF, Tsai WY (Lai F as part of the International Down Syndrome and Alzheimer's Disease Consortium). Assessment of aging individuals with Down syndrome in clinical trials: results of baseline measures.  J Policy Practice in Intell Disabilities 2005:126-138.

    Wegiel J, Kaczmarski W, Barua M et al (including Lai F). Link between KYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.  J. Neuropathol Exp Neurol 2011;70:36-50.

Reviews: Comments and Ratings