Deborah Mitchell, MD
Deborah Mitchell, MD
Assistant Pediatrician, Massachusetts General Hospital
Program Director, Fellowship Training Program
Departments, Centers, & Programs:
Mass General for Children: Pediatric Endocrine Program and Diabetes Center
55 Fruit St.
Boston, MA 02114
- MD, Harvard Medical School
- Fellowship, Massachusetts General Hospital*****
American Board Certifications
- Pediatric Endocrinology, American Board of Pediatrics
- Pediatrics, American Board of Pediatrics
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Dr. Mitchell's research is concerned with factors which promote optimal bone growth and mineralization during childhood and adolescence, with a goal of preventing osteoporosis and fractures in adults. She is currently investigating bone accrual and microarchitecture in children with type 1 diabetes, a condition known to increase the risk of bone fragility. Her goal is to better understand why patients with diabetes are at increased risk of fracture in order to be able to design and test therapies to strengthen bones in this population.
In addition, Dr. Mitchell is interested in rare disorders of calcium and phosphate metabolism including hypoparathyroidism, pseudohypoparathyroidism, and X-linked hypophosphatemic rickets. In particular, her research has demonstrated extremely high rates of kidney disease among patients treated for hypoparathyroidism. Ongoing studies are investigating determinants of renal disease in this population as well as novel, targeted therapies.
Selected Research Articles:
- Mitchell DM, Caksa S, Joseph T, Bouxsein ML, Misra M. 2020. Elevated HbA1c is associated with altered cortical and trabecular microarchitecture in girls with type 1 diabetes. J Clin Endo Metab.
- Mitchell DM, Caksa S, Yuan A, Bouxsein ML, Misra M, Burnett-Bowie SM. 2018. Trabecular bone morphology correlates with skeletal maturity and body composition in healthy adolescent girls. J Clin Endocrinol Metab.
- Mitchell D.M., Jüppner H, Burnett-Bowie SM. 2017. FGF23 is not associated with age-related changes in phosphate but enhances renal calcium reabsorption in girls. J Clin Endo Metab.
- Mitchell D.M., Leder B.Z., Cagliero E. Mendoza N., Henao M.P., Hayden D.L., Finkelstein J.S., and Burnett-Bowie S.M. 2015. Insulin secretion and sensitivity in healthy adults with low vitamin D are not affected by high-dose ergocalciferol administration: a randomized controlled trial. Am Journal of Clin Nutr
- Mitchell D.M., Regan S., Cooley M.R., Lauter K.B., Vrla M.C., Becker C.B., Burnett-Bowie S.M., and Mannstadt M. 2012. Long-term follow-up of patients with hypoparathyroidism. J Clin Endo Metab
- Mitchell D.M. 2017 Growth in patients with type 1 diabetes. Curr Opin Endo Diab Obes.
- Mitchell D.M. and Jüppner H. 2010. Regulation of calcium homeostasis and bone metabolism in the fetus and neonate. Curr Opin Endo Diab Obes.