What is Multiple Endocrine Neoplasia: Type 1 (MEN-1)?

Multiple endocrine neoplasia is a group of disorders that leads to tumors (growth of tissue) in different endocrine glands (the system that makes and regulates hormones). There are several types of multiple endocrine neoplasia. One common type of this disorder is multiple endocrine neoplasia type 1 (or MEN-1). It is also known as Wermer syndrome.

MEN-1 is a genetic condition caused by mutations (changes) in the MEN1 gene. This gene usually prevents the growth of tumors. In people with MEN-1, the mutation prevents the gene from working properly. This can lead to the growth of multiple tumors in the endocrine system.

Did You Know...?

Not all tumors are dangerous. Tumors can be benign (non-cancerous) or malignant (cancerous). The tumors caused by MEN-1 usually lead to an increased secretion of certain hormones. They may or may not be malignant.

Learn More

Rev. 11/2019. MassGeneral Hospital for Children and Massachusetts General Hospital do not endorse any of the brands listed on this handout. This handout is intended to provide health information so that you can be better informed. It is not a substitute for medical advice and should not be used to treatment of any medical conditions.