What are the Signs and Symptoms of Multiple Endocrine Neoplasia Type 1 (MEN-1)?

There are many symptoms related to multiple endocrine neoplasia type 1 (MEN-1). Most occur because of increased secretion (production) of certain hormones.

Common conditions associated with MEN-1 include:

  • Endocrine tumors in the pancreas, pituitary gland and parathyroid glands
  • Hyperparathyroidism, a condition in which the parathyroid glands (four small glands that lie behind the thyroid gland, a butterfly-shaped gland in the front of the neck) become overactive and disrupt the balance of calcium and phosphorus in blood, causing high levels of calcium and low levels of phosphorus. This may in turn be associated with:
    • Kidney stones
    • Fragile bones
  • Pituitary tumors, which commonly include tumors that make too much prolactin (prolactinomas), or ACTH (a hormone that stimulates that adrenal glands to make cortisol), or sometimes growth hormone. Symptoms are related to increased secretion of the specific hormone
  • Tumors in the stomach, duodenum or pancreas
    • Zollinger-Ellison syndrome, a condition where the tumor (known as a gastrinoma) causes the stomach to make too much acid. This in turn causes:
      • Ulcers (sores) in the stomach or upper intestine
    • Pancreatic tumors which include tumors that make too much insulin (insulinomas), as well as other hormone secreting tumors
  • Non-endocrine tumors
    • Facial angiofibromas, which are small red bumps that grow on the face, especially around the nose and cheeks
    • Collagenomas
    • Lipomas, leiomyomas, meningiomas, and ependymomas

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Rev. 11/2019. MassGeneral Hospital for Children and Massachusetts General Hospital do not endorse any of the brands listed on this handout. This handout is intended to provide health information so that you can be better informed. It is not a substitute for medical advice and should not be used to treatment of any medical conditions.