A Massachusetts General Hospital research team, using the kidney as an example, has developed a way to avoid ischemia/reperfusion injury with a new monoclonal antibody that binds its target in a way that is "just right."
A heart attack happens when the blood supply is cut off from the heart muscle, usually because of a blood clot. Without blood and oxygen, the muscle cells are damaged and die.
Featured Treatment Areas
Corrigan Minehan Heart Center
During cardiac catheterization, Massachusetts General Hospital physicians use digital images to identify narrowing or blockage in the arteries.
Mass General Imaging provides full cardiac CT services in Boston and additional cardiac CT services in Chelsea and Waltham.
Corrigan Minehan Heart Center
Cardiac Rehabilitation Program
A program in the Cardiovascular Disease Prevention Center designed to treat patients who have been diagnosed with heart disease, including angina and coronary heart disease, or have had a heart attack, bypass graft surgery or angioplasty.
Corrigan Minehan Heart Center
The Massachusetts General Hospital Cardio-Oncology Program provides care at the intersection of heart and vascular disease, and cancer. The program focuses on improving the health of cancer patients and cancer survivors by providing comprehensive cardiac and vascular care.
Corrigan Minehan Heart Center
Cardiovascular Disease Prevention Center
The Cardiovascular Disease Prevention Center at the Massachusetts General Hospital Corrigan Minehan Heart Center takes a prevention-as-treatment approach to caring for the heart and overall cardiovascular system.
What is a heart attack?
A heart attack is also called a myocardial infarction. It happens when one or more parts of the heart muscle don?t get enough oxygen. That occurs when blood flow to the heart muscle is blocked.
If the blood and oxygen supply is cut off, muscle cells of the heart begin to suffer damage and start to die. Lasting (permanent) damage begins within 30 minutes of blockage. The heart muscle may then no longer work as it should.
What causes a heart attack?
A blockage in the arteries can lead to a heart attack. A blockage is caused by a buildup of plaque. This is called atherosclerosis. Plaque is made up of deposits, cholesterol, and other substances. When a plaque breaks (ruptures), a blood clot quickly forms. The blood clot is the actual cause of the heart attack.
Who is at risk for a heart attack?
A heart attack can happen to anyone. But certain factors can raise your risk for one. Some of these factors you can?t change. Others you may be able to manage through lifestyle changes and medical care.
You may be at higher risk for a heart attack if you:
Have high blood pressure
Have low levels of high-density lipoprotein (HDL) cholesterol, high levels of low-density lipoprotein (LDL) cholesterol, or high levels of triglycerides.
Have a family history of heart disease. This is especially true if the heart disease started before age 55.
Are older in age. Generally, men are at risk at a younger age than women. After menopause, women are equally at risk.
Smoke, including chewing tobacco and electronic cigarettes (vaping)
Are under a lot of stress
Drink too much alcohol or use illegal drugs
Are not active
Eat a diet high in saturated fat and low in fiber
What are the symptoms of a heart attack?
Each person may have slightly different symptoms of a heart attack. But these are the most common symptoms:
Severe pressure, fullness, squeezing, pain, or discomfort in the center of the chest that lasts for more than a few minutes
Pain or discomfort that spreads to the shoulders, neck, arms, or jaw
Chest pain that gets worse
Chest pain that doesn't get better with rest or by taking nitroglycerin
Chest pain that happens along with any of these symptoms:
Cool, clammy skin or paleness
Shortness of breath
Nausea or vomiting
Dizziness or fainting
Unexplained weakness or fatigue
Fast or irregular pulse
Chest pain is the key warning sign of a heart attack. But it may be confused with other conditions. These include heartburn, pleurisy, and pneumonia. Always see your healthcare provider for a diagnosis.
How is a heart attack diagnosed?
If you or someone you know has any of the warning signs for a heart attack, act right away. Call 911 or your local emergency number. Don?t drive yourself to the hospital or emergency department if you think you are having a heart attack.
Diagnosing a heart attack often happens in an emergency department. There, a healthcare provider will ask you about your health history and do a physical exam. You may also need some tests, such as:
Electrocardiogram (ECG). This test checks the electrical activity of your heart. It can find signs of a heart attack.
Blood work. These tests can find certain proteins that the body may make during a heart attack.
Coronary angiography. During this test, X-ray dye (contrast medium) is put into your coronary arteries. Special X-rays (angiograms) are then taken. They show how well blood is flowing through your heart and blood vessels. The test can find blockages in an artery.
How is a heart attack treated?
The goal of treatment for a heart attack is to ease pain, restore blood flow to the coronary artery, preserve the heart muscle function, and prevent death. Treatment may include:
IV (intravenous) therapy. Medicines such as nitroglycerin and morphine are given through a tube into a vein.
Oxygen therapy. This treatment can give the damaged heart muscle more oxygen.
Pain medicines. These can decrease the workload and oxygen demand of the heart.
Cardiac medicine such as beta-blockers. These can help the heart muscle rest, prevent an irregular heartbeat and decrease heart rate and blood pressure.
Fibrinolytic therapy. Medicine is given by IV to dissolve the blood clot, restoring blood flow.
Antithrombin or antiplatelet therapy with aspirin or clopidogrel. This is used to prevent more blood clotting.
Medicines that lower cholesterol, particularly LDL cholesterol. These include medicines such as statins. Newer medicines called PCSK9-inhibitors are for people with inherited high cholesterol. Ask your healthcare provider if these medicines can help prevent a heart attack.
You may also need other procedures to restore blood flow to the heart. These are described below.
Percutaneous coronary intervention (PCI) or coronary angioplasty
This procedure opens up a blocked or narrowed coronary artery. There are several ways to do so. A small balloon may be inflated inside the blocked artery to open the blocked area. The blocked area may be cut away with a special device or vaporized with a laser. A tiny coil called a stent is often expanded inside the artery. The stent remains in place to help keep the artery open.
Coronary artery bypass
This surgery is also called bypass surgery or CABG (pronounced "cabbage"). It is often done in people who have chest pain (angina) and coronary artery disease. During the surgery, the surgeon makes a bypass to let blood flow around the blockage. This is done by grafting a piece of a vein from the aorta. This is grafted onto the coronary artery beyond the blocked part of the artery. The surgeon often takes veins from a leg. But they may also use arteries from the chest or an arm.
What are possible complications of a heart attack?
The possible complications of a heart attack include:
Damage to the heart or heart valves
Abnormal heart rhythms
Another heart attack
What can I do to prevent a heart attack?
Talk with your healthcare provider about your risk for a heart attack. You may be able to prevent a heart attack by:
Lowering the levels of your blood pressure, LDL cholesterol, and triglycerides, if needed
Lowering your stress levels
Not drinking too much alcohol
Being more physically active
Losing weight, if needed
Eating a healthy, low-fat diet
Key points about a heart attack
A heart attack happens when one or more areas of the heart muscle don?t get enough oxygen. This happens when blood flow to the heart muscle is blocked.
A blood clot is the actual cause of a heart attack. It can form when there is a blockage in the arteries from plaque buildup.
Having high blood pressure and a family history of heart disease can raise your risk for a heart attack.
Severe chest pain or discomfort is often a symptom of a heart attack. But you may also feel short of breath, nauseous, and dizzy.
A coronary angiogram can find blockages in an artery.
Treatment includes medicines and procedures to restore blood flow to the heart.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells you.
At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that visit.
Know how you can contact your provider if you have questions.
News & Publications
The Patient Gateway provides secure online access to your health information whenever you need it. Check upcoming appointments, communicate with your doctor’s office, review medications and pay medical bills—all seamlessly online 24/7.