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Detailed information on the different types of polycystic kidney disease.
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Polycystic kidney disease (PKD) is a rare genetic disorder. It causes cysts filled with fluid to grow in the kidneys. PKD cysts can impair how the kidneys work. If numerous cysts grow or become enlarged, this may lead to kidney failure. People with PKD can also have cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain.
PKD is the fourth leading cause of kidney failure. It affects about 600,000 people in the U.S., according to the National Kidney Foundation. About half of people with the autosomal dominant form of PKD end up with kidney failure by age 50. About 3 in 5 will have kidney failure by age 70.
There are two main forms of PKD that are inherited.
Autosomal dominant PKD (ADPKD) is the most common form of PKD. It accounts for about 90% of all PKD cases. Autosomal dominant means that if one parent has the disease, there is a 50% chance that the disease will pass to a child. Both males and females are equally affected.
ADPKD used to be called adult polycystic kidney disease. It is often diagnosed in adulthood. Usually, at least one parent must have the disease for a child to inherit it. In 1 in 10 cases, there may be no family history of PKD. These cases are new mutations in a family. In very few cases, this type of PKD happens suddenly after conception. Parents would not be at increased risk to have more children with PKD. But people with PKD have a 50/50 chance of passing the gene on to their children.
Symptoms often start between age 30 and 40. But they can begin in childhood. They may include:
Belly pain
Detectable belly mass
Pale color to skin
Easy bruising
High blood pressure
Kidney stones
Bulging of the walls of blood vessels (aneurysms) in the brain
Pouches in the intestines (diverticulosis)
Urinary tract infections
Blood in the urine (hematuria)
Liver and pancreatic cysts
Abnormal heart valves
ADPKD may happen with other conditions, such as:
Tuberous sclerosis (a genetic syndrome involving seizures, intellectual disability, benign tumors, and skin lesions)
Liver disease
Severe eye problems
The symptoms of ADPKD sometimes look like other health problems. Always see your healthcare provider for a diagnosis.
Diagnosis of ADPKD may include the use of imaging tests to detect cysts on the kidney and other organs and a review of the family history. There are three different dominant genes that have been identified. They further subdivide this type into PKD1, PKD2, and PKD3.
A healthcare provider will create a treatment plan after careful consideration of symptoms and health history. Treatment may include:
Pain medicine
Surgery to shrink cysts and ease pain
Treatment for high blood pressure
Treatment for urinary tract infections
Dialysis
Kidney transplant
Autosomal recessive PKD (ARPKD) is a rare form of PKD. It is thought to be caused by a particular genetic flaw. This is different from the genetic flaw that causes ADPKD. Parents who don't have the disease can have a child with the disease if both parents carry the abnormal gene and both pass the gene to their child. Carrier parents have a 1 in 4 chance with each pregnancy to have a child with this type of PKD. All adults are equally affected.
ARPKD is sometimes found before birth (prenatally) using a fetal ultrasound. Symptoms can start before birth. In most cases, the earlier the onset, the more severe the outcome.
Children born with ARPKD may develop kidney failure in a few years. They often have:
High blood pressure
Urinary tract infections
Frequent urination
The disease also often affects the liver, spleen, and pancreas. This results in low blood cell counts, varicose veins, and hemorrhoids.
The symptoms of ARPKD may look like other health problems. Always talk with a healthcare provider for a diagnosis.
Diagnosis often includes ultrasound imaging of the developing baby or newborn to reveal cysts in the kidneys. An ultrasound exam of kidneys of relatives may also be helpful.
A healthcare provider will figure out a treatment plan for ARPKD after careful consideration of the child's symptoms and health history. Treatment may include:
Treatment for high blood pressure
Treatment for urinary tract infections
Hormonal therapy
Dialysis
Kidney transplant
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