About M. Amin Arnaout, MD

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Dr. Arnaout is a physician-scientist in the Department of Medicine at Massachusetts General Hospital in Boston. He is Chief-Emeritus of the Division of Nephrology at Massachusetts General Hospital, and Professor of Medicine at Harvard Medical School.

Dr. Arnaout received his medical degree with distinction from the American University of Beirut, Lebanon. He served on the medical staff of the American University of Beirut Hospital as an intern and resident in Medicine before moving to Johns Hopkins where he completed his residency. He then moved to Harvard where he finished fellowships in immunology and nephrology at Boston's Childrens Hospital and Brigham and Women's Hospital.

Dr. Arnaout is a physician-scientist and served as Chief of the Division of Nephrology at Massachusetts General Hospital from 1998-2013. He received many awards including the 2018 Homer W Smith Award from the American Society fo Nephrology presented annually to an individual "who has made outstanding contributions which fundamentally affect the science of nephrology".  He currently serves as a practicing physician, Principal Investigator on several Federal grants and  Director of the Leukocyte Biology & Inflammation Program and the Structural Biology Program in the Department of Medicine and Nephrology at Massachusetts General Hospital. 

Departments, Centers, & Programs:

Clinical Interests:




Mass General Renal Associates
165 Cambridge Street
Suite 302
Boston, MA 02114
Phone: 617-726-5050

Medical Education

  • MD, American University - Beirut, Faculty of Medicine
  • Residency, Johns Hopkins Hospital***
  • Fellowship, Boston Children's Hospital
  • Fellowship, Brigham and Women's Hospital

American Board Certifications

  • Internal Medicine, American Board of Internal Medicine
  • Nephrology, American Board of Internal Medicine

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


Our laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state of the art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease. Areas of interest include integrin biology and structure, pathogenesis of autosomal dominant polycystic kidney disease, lineage commitment in hematopoietic stem cells, mechanisms of ischemic acute kidney injury and engineering kidney assist devices.



  • Selected:

    • Arnaout MA, Pitt J, Cohen HJ, Melamed J, Rosen FS, Colten HR. 1982. N Engl J Med. 306:693.
    • Dana N, Todd RF 3rd, Pitt J, Springer TA, Arnaout MA. 1984. J Clin Invest. 73:153.
    • Arnaout MA, Hakim RM, Todd RF, Dana N, Colten HR.1985.  N Engl J Med. 312:457.
    • Michishita M, Videm V, Arnaout MA. 1993. Cell. 72: 857.
    • Lee JO, Rieu P, Arnaout MA (Corresponding Author), Liddington R. 1995. Cell. 80:631.
    • Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA. 2000.  
      Proc. Natl Acad. Sci. USA. 97:1731.
    • Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, Scott DL, Joachimiak A, Goodman SL,
      Arnaout MA. 2001. Science. 294:339.
    • Xiong JP, Stehle T, Zhang R, Dunker R, Joachimiak A, Frech M, Goodman SL, Arnaout MA. 2002.  
      Science. 296:151.
    • Van Agthoven JF, Xiong JP, Rui X, Alonso JL, Adair BD, Goodman SL, Arnaout MA. 2014.  Nature
      Struc Mol Biol
    • Dehnadi A, Benedict Cosimi A, Neal Smith R, Li X, Alonso JL, Means TK, Arnaout MA. 2017. Nature
      8:13899. doi: 10.1038/ncomms13899.
    • Van Agthoven JF, Shams H, Cochran FV, Alonso JL, Kintzing JR, Garakani K, Adair BD, Xiong JP,
      Mofrad MRK, Cochran JR, Arnaout MA. 2019. Structure 27(9):1443.


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