Jeremy Schmahmann, MD
Jeremy Schmahmann, MD
Director, Laboratory for Neuroanatomy and Cerebellar Neurobiology
Member, Cognitive Behavioral Neurology Unit
Departments, Centers, & Programs:
Department of Neurology
15 Parkman Street
Boston, MA 02114-3117
- MD, University of Cape Town
- M.B., CH.B.,University of Cape Town School of Medicine, South Africa
- Residency, Boston City Hospital
- Residency, Brockton Veterans Administration Medical Center
- Fellowship, Boston University School of Medicine
American Board Certifications
- Neurology, American Board of Psychiatry and Neurology
- Electrodiagnostic Medicine, American Board of Electrodiagnosic Medicine
- Behavioral Neurology and Neuropsychiatry, United Council for Neurologic Subspecialties
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Structure and function of the cerebellum: Our lab focuses on structural and functional topography in the human cerebellum in health and disease, using MRI techniques.
Outcome measures in ataxia: We quantify ataxia using the Brief Ataxia Rating Scale (BARS) together with machine learning to develop observer independent, quantitative, real time analysis of motor control in patients with ataxia and other movement disorders. We use the cerebellar cognitive affective / Schmahmann syndrome scale to detect and quantitate the degree of cognitive and emotional impact in patients with cerebellar diseases; the Patient Reported Outcome Measure for Ataxia (PROM-Ataxia) to capture patient experience, and we are developing a CCAS pediatric scale, a pediatric BARS, and refining the cerebellar neuropsychiatric rating scale.
Natural History studies and clinical trials in ataxia: We are engaged in the National Ataxia Foundation (NAF) and clinical research consortium for the study of cerebellar ataxia (CRC-SCA) natural history study, the NIH-sponsored READISCA study and MRI study of MRI spectroscopy in spinocerebellar ataxia, and the ESMI study - European collaborative investigation of spinocerebellar ataxia type 3; we are a lead clinical site for Biohaven’s troriluzole study in SCA 1, 2, 3, and 6; Biohaven’s verdiperstat study in multiple system atrophy; and about to start Biogen’s ASO study in SCA3.
Schmahmann JD. An emerging concept: The cerebellar contribution to higher function. Arch. Neurol. 1991;48:1178-1187.
Schmahmann JD and Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998; 121:561-579.
Schmahmann JD. The role of the cerebellum in cognition and emotion: Personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy. Neuropsychol Rev. 2010;20:236-60.
Hoche F, Guell X, Vangel MG, Sherman JC, Schmahmann JD. The cerebellar cognitive affective/Schmahmann syndrome scale. Brain. 2018;1411:248-270.
Schmahmann JD, Guell X, Stoodley CJ, Halko MA. The Theory and Neuroscience of Cerebellar Cognition. Annu Rev Neurosci. 2019;42:337-364.
Guell X, Gabrieli JDE, Schmahmann JD. Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort. Neuroimage. 2018;172:437-449.
Schmahmann JD. (Editor). The Cerebellum and Cognition. International Review of Neurobiology. Volume 47. San Diego, Academic Press. 1997.
Schmahmann JD, Doyon J, Toga A, Petrides M, Evans A. MRI Atlas of the Human Cerebellum. San Diego, Academic Press. 2000.
Schmahmann JD, Pandya DN. Fiber Pathways of the Brain. New York, Oxford University Press. 2006.
Boltshauser E, Schmahmann JD. (Editors). Cerebellar Disorders in Children. Clinics in Developmental Medicine No. 191 – 192. London, MacKeith Press.
Manto M, Gruol D, Schmahmann JD, Koibuchi N, Rossi (Editors). Handbook of the Cerebellum and Cerebellar Disorders. New York, Springer. 2012.