Researchers have used a genetic engineering strategy to dramatically reduce levels of tau—a key protein that accumulates and becomes tangled in the brain during the development of Alzheimer’s disease—in an animal model of the condition.
Departments, Centers, & Programs:
15 Parkman Street
Boston, MA 02114-3117
- PhD, University of Iowa Carver College of Medicine
- MD, University of Iowa College of Medicine
- Residency, University of Iowa Hospital & Clinics
American Board Certifications
- Neurology, American Board of Psychiatry and Neurology
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Dr Hyman's research focuses on Alzheimer Disease and Lewy Body Dementias, spanning patient care, diagnostic and therapeutic issues, and neuropathology. He also directs a basic science program dedicated to understanding the underlying biology of dementias, how genetic risk factors impact the diease, and how to develop new therapies that may help patients.
(selected from >500 papers and chapters
1. de Calignon A, et al Casapse activation precedes and leads to tangles. Nature 2010 Apr 22;464(7292):1201-4
15. Serrano-Pozo A, et al Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain. 2010 May;133(Pt 5):1312-27.
- Press Release
- Jun | 22 | 2020
Different "Subtypes" of Alzheimer’s May be Linked to Different Modifications of the Tau Protein, Mass General-led Team Finds
A new study reveals a possible biological reason that Alzheimer’s Disease progresses at different rates in different patients.
- Dec | 11 | 2013
Neurofibrillary tangles - largely composed of tau protein- are one of the two pathological hallmarks of Alzheimer’s disease.