Neurofibrillary tangles - largely composed of tau protein- are one of the two pathological hallmarks of Alzheimer’s disease.
Departments, Centers, & Programs:
15 Parkman Street
Boston, MA 02114-3117
- PhD, University of Iowa Carver College of Medicine
- MD, University of Iowa College of Medicine
- Residency, University of Iowa Hospital & Clinics
American Board Certifications
- Neurology, American Board of Psychiatry and Neurology
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Dr Hyman's research focuses on Alzheimer Disease and Lewy Body Dementias, spanning patient care, diagnostic and therapeutic issues, and neuropathology. He also directs a basic science program dedicated to understanding the underlying biology of dementias, how genetic risk factors impact the diease, and how to develop new therapies that may help patients.
(selected from >500 papers and chapters
1. de Calignon A, et al Casapse activation precedes and leads to tangles. Nature 2010 Apr 22;464(7292):1201-4
15. Serrano-Pozo A, et al Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain. 2010 May;133(Pt 5):1312-27.