About Tatsuo Kawai, MD, PhD

Tatsuo Kawai MD, PhD is Professor of Surgery Harvard Medical School and A. Benedict Cosimi Chair in Transplant Surgery at Massachusetts General Hospital. He is also the Surgical Director of living donor transplantation and the dialysis access program. He specializes in kidney, pancreas and liver transplantation as well as hemodialysis access surgery. He received his M.D. from Nihon University School of Medicine and Ph.D. from Tokyo Women’s Medical University, Tokyo, Japan. He completed surgical residency at Tokyo Women’s Medical University and clinical fellowship at Massachusetts General Hospital.  His clinical and research interests are primarily focused on development of methods to induce immunological tolerance in organ/cell transplantation. He was the first to report a consistent model for induction of renal allograft tolerance in nonhuman primates through a mixed chimerism approach. This and subsequent pre-clinical reports have extended this approach to the world’s first clinical trials for induction of renal allograft tolerance in HLA mismatched kidney transplantation. This is a seminal achievement of a clinical protocol leading to the first reproducibly successful induction of renal allograft tolerance in humans and was reported in the New England Journal of Medicine in 2008 and 2013. He was awarded the Martin Research Prize at MGH in 2009 and the New Key Opinion Leader Award by the Transplantation Society in 2010 for this work.

Clinical Interests:

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Locations

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696
617-726-0289
617-724-9996
Fax: 617-726-9322

Medical Education

  • MD, Nihon University
  • PhD, Tokyo Women's Medical University
  • Residency, Kawasaki City Hospital
  • Residency, Tokyo Women's Medical University
  • Fellowship, Massachusetts General Hospital

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Research

The induction of donor-specific tolerance is currently one of the most important goals of organ or cell transplantation.

Based on our rodent studies on mixed chimerism, we developed a clinically relevant non-myeloablative preparative regimen to induce mixed chimerism and renal allograft tolerance following donor bone marrow transplantation in MHC fully-mismatched cynomolgus monkeys. This approach has been successfully extended to HLA mismatched kidney transplant recipients. In 4/5 recipients who were treated with our mini-bone marrow transplant, immunosuppression was successfully discontinued at 9-14 months following the transplant in the other four recipients with longest survival exceeding 7 years. Since January 2009, an expanded, multi-center clinical trial for tolerance induction following HLA mismatched kidney transplantation has been underway.

Publications

  • View my most recent publications at PubMed

    Select Publications:  From a  total of 124 peer-reviewed manuscripts, 57 Reviews and 17 Textbook chapters have been published as of Dec 2009. 

    • Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59 (2): 256.
    • Kawai T, Sogawa H, Boskovic S, et al. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004; 4 (9): 1391.
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358 (4): 353.