Departments, Centers, & Programs:
Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696
- MD, Nihon University
- PhD, Tokyo Women's Medical University
- Residency, Kawasaki City Hospital
- Residency, Tokyo Women's Medical University
- Fellowship, Massachusetts General Hospital
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The induction of donor-specific tolerance is currently one of the most important goals of organ or cell transplantation.
Based on our rodent studies on mixed chimerism, we developed a clinically relevant nonmyeloablative preparative regimen to induce mixed chimerism and renal allograft tolerance following donor bone marrow transplantation in MHC fully-mismatched cynomolgus monkeys. This approach has been successfully extended to HLA mismatched kidney transplant recipients. In 4/5 recipients who were treated with our mini-bone marrow transplant, immunosuppression was successfully discontinued at 9-14 months following the transplant in the other four recipients with longest survival exceeding 7 years. Since January 2009, an expanded, multi-center clinical trial for tolerance induction following HLA mismatched kidney transplantation has been underway.
Select Publications: From a total of 124 peer-reviewed manuscripts, 57 Reviews and 17 Textbook chapters have been published as of Dec 2009.
- Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59 (2): 256.
- Kawai T, Sogawa H, Boskovic S, et al. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant 2004; 4 (9): 1391.
- Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358 (4): 353.