About Matthew Smith, MD, PhD

Dr. Matthew R. Smith is Director of the Genitourinary Oncology Program at Massachusetts General Hospital Cancer Center and an Associate Professor of Medicine at Harvard Medical School. He graduated summa cum laude from Canisius College with a B.A. in biochemistry. He received his MD and PhD degrees from Duke University School of Medicine. He trained in Internal Medicine at Brigham and Women's Hospital. He completed a fellowship in Medical Oncology at Dana Farber Cancer Institute and a postdoctoral fellowship at Massachusetts Institute of Technology.

He is an internationally recognized expert in prostate cancer. He has published extensively on treatment and prevention of bone metastases and prostate cancer survivorship. He has authored more than 150 peer-reviewed articles including manuscripts in New England Journal of Medicine, Journal of Clinical Oncology, Cancer, Journal of Clinical Endocrinology and Metabolism, and Clinical Cancer Research. His research is supported by competitive grants and awards from the National Institutes of Health, Lance Armstrong Foundation Research Award, and the Prostate Cancer Foundation.

Departments, Centers, & Programs:

Clinical Interests:



Mass General Cancer Center: Center for Genitourinary Cancers
55 Fruit St.
Boston, MA 02114
Phone: 617-724-4000

Mass General Cancer Center in Waltham
52 Second Ave.
Suite 1110
Waltham, MA 02451
Phone: 781-487-6100

Medical Education

  • MD, Duke University School of Medicine
  • Residency, Brigham and Women's Hospital
  • Fellowship, Dana Farber Cancer Institute

American Board Certifications

  • Medical Oncology, American Board of Internal Medicine

Accepted Insurance Plans

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Dr. Smith leads a clinical research program in prostate cancer focused on cancer survivorship, treatment and prevention of bone metastases, and novel therapeutics. With a multidisciplinary research team, he identified previously unrecognized adverse effects of androgen deprivation therapy including osteoporosis, sarcopenia, obesity, lipid alterations, insulin resistance, and greater risks for fractures, diabetes, and cardiovascular disease. These novel observations have provided fundamental insights in the management of prostate cancer and informed the design of global clinical trials to prevent treatment-related morbidity in prostate cancer survivors. His research has contributed to the approval of new drugs to prevent skeletal morbidity in men with prostate cancer. He leads international studies to prevent and treat bone metastases. He leads an active clinical research program in novel therapy for prostate cancer. His research program is supported by principal investigator peer-reviewed research funding from federal, investigator-initiated industry, and foundation grants including an NIH K24 mid-career investigator award and a Prostate Cancer Foundation Transformational grant. He has authored more than 70 original research reports and more than 80 reviews and book chapters on prostate cancer.


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