About Moussa Mansour, MD

Moussa Mansour, MD, is Professor of Medicine at Harvard Medical School. He is also Director of the Atrial Fibrillation Program, and the Jeremy Ruskin and Dan Starks Endowed Chair in Cardiology, at Massachusetts General Hospital. 

Dr. Mansour’s clinical and research interest focuses on atrial fibrillation and his aim is to enhance the understanding of this disease and improve the quality of care of patients suffering from it. He has pioneered the use of new techniques and technologies aiming at making ablation for atrial fibrillation safer and more effective.

Dr. Mansour is also an active clinical consultant in all aspects of heart rhythm disorders, including atrial fibrillation, ventricular tachycardia, supraventricular tachycardia, bradycardia and other abnormal rhythms. Dr. Mansour performs a large number of catheter ablation procedures and implants pacemakers and defibrillators to treat different arrhythmias.

Dr. Mansour has published extensively in the field of cardiac arrhythmia, specifically the area of atrial fibrillation. He is involved in cutting edge research and participates in the development of new catheters and techniques for the ablation of atrial fibrillation. Most recently he has been heavily involved in investigating pulsed-field ablation for atrial fibrillation, which is novel technology that has the potential to make ablation for atrial ablation safer and more effective.

In addition to catheter ablation, Dr. Mansour is an expert in the occlusion of the left atrial appendage using tools such as the Watchman devices for stroke prevention in patients with atrial fibrillation. He is involved in studies investigating new generations of this device that are safer and more effective.

Departments, Centers, & Programs:

Clinical Interests:




Mass General: Demoulas Center for Cardiac Arrhythmias
55 Fruit St.
Boston, MA 02114
Phone: 617-724-4500

Medical Education

  • MD, American University - Beirut, Faculty of Medicine
  • Residency, Detroit Medical Center
  • Fellowship, Massachusetts General Hospital
  • Fellowship, State University of New York Upstate Medical University

American Board Certifications

  • Cardiovascular Disease, American Board of Internal Medicine
  • Clinical Cardiac Electrophysiology, American Board of Internal Medicine

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Dr. Mansour's area of research is catheter ablation for atrial fibrillation. He is participating in numerous clinical studies with the objective of finding safer and more effective ways to treat this arrhythmia. One of the tools he is investigating and actively working with is pulsed-field ablation, and he is leading major projects in this field. Another area of research that Dr Mansour is involved in is stroke prevention for atrial fibrillation using tools for left atrial appendage occlusion, such as the Watchman device, which provides significant benefits for patients with atrial fibrillation and difficulty taking blood thinners.


  • Selected publications:

    1. Hucker W, Cohen J, Gurol E, Heist EK, Gianni C, Galvin J, Atkins D, Bommana S, Ruskin J, Mohanty S, Horton R, Lakkireddy D, Natale A, Mansour M. WATCHMAN implantation in patients with a history of atrial fibrillation and intracranial hemorrhage. J Interv Card Electrophysiol. 2020 Nov;59(2):415-421.

    2. Mansour M, Calkins H, Osorio J, Pollak S, Melby D, Marchlinski F, Athill C, Delaughter C, Patel A, Gentlesk P, DeVille B, Macle L, Ellenbogen K, Dukkipati S, Reddy V, Natale A. Persistent atrial fibrillation ablation with contact force sensing catheter: The prospective multicenter PRECEPT Trial. JACC Clin Electrophysiol. 2020 Aug;6(8):958-969.

    3. Very High-Power Short-Duration, Temperature-Controlled Radiofrequency Ablation in Paroxysmal Atrial Fibrillation: The Prospective Multicenter Q-FFICIENCY Trial. Osorio J, Hussein AA, Delaughter MC, Monir G, Natale A, Dukkipati S, Oza S, Daoud E, Di Biase L, Mansour M, Fishel R, Valderrabano M, Ellenbogen K; Q-FFICIENCY Trial Investigators. JACC Clin Electrophysiol. 2023 Apr;9(4):468-480.

    4. Contact force catheter ablation for the treatment of persistent atrial fibrillation: Results from the PERSIST-END study.Lo M, Nair D, Mansour M, Calkins H, Reddy VY, Colley BJ 3rd, Tanaka-Esposito C, Sundaram S, DeLurgio DB, Sanders P, Khatib S, Bernard M, Olson N, Gibson D, Miller A, Li J, Natale A. J Cardiovasc Electrophysiol. 2023 Feb;34(2):279-290.

    5. Deng W, Mansour M, Song B, Hou H, Liu K, Xu Y, McMullin D, Buonanno FS, Lo EH, Ning M. Fall Outcomes With Left Atrial Appendage Occlusion vs Direct Oral Anticoagulants for Atrial Fibrillation. J Am Coll Cardiol. 2023 Jul 25;82(4):379-381.

    6. Reddy V, Gerstenfeld E, Natale A, Whang W, Cuoco F, Patel C, Mountantonakis S, Gibson D, Harding J, Ellis C, Ellenbogen K, DeLurgio D, Osorio J, Achyutha A, Schneider C, Mugglin A, Albrecht E, Stein K, Lehmann J, and Mansour M, for the ADVENT Investigators. Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2023 DOI: 10.1056/NEJMoa230729

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