John Chen, MD, PhD
John Chen, MD, PhD
Director, Institute for Innovation in Imaging, Department of Radiology
Director, Imaging Clinical Trials, Division of Neuroradiology
Associate Professor of Radiology, Harvard Medical School
About John Chen, MD, PhD
Dr. Chen is an associate radiologist and director of Imaging Clinical Trials in the Division of Neuroradiology and director of the Institute for Innovation in Imaging in the Department of Radiology.
Dr. Chen is an associate professor of Radiology at Harvard Medical School and attending clinician in the Department of Radiology (Neuroradiology) at Massachusetts General Hospital. He is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency in 2004 and neuroradiology fellowship at Mass General in 2005. He has won several awards including the Mass General Wyman Award, RSNA and Dana Foundation Awards as well as an NIH K08 award. His current research is supported by two NIH R01 and an R21 grants.
Clinical Interests:
- Neuroradiology
- Multiple sclerosis
- Neurodegenerative disorders
- Stroke
- Brain tumors
- Advanced MR techniques
- Stroke Imaging
- Oncologic imaging
- Carotid occlusive disease
- Dementia
- Memory loss
- Molecular imaging
- Imaging contrast agents
Treats:
- Adult
Locations
Division of Neuroradiology, Department of Radiology
55 Fruit St
Boston, MA 02114-2696
Phone: 617-726-8320
Phone: 617-726-1578
Fax: 617-724-3338
Medical Education
- MD, University of Illinois College of Medicine
- MD, University of Illinois College of Medicine at Urbana-Champaign
- PhD, University of Illinois College of Medicine at Urbana-Champaign
- Residency, Mass General Hospital
- Residency, Massachusetts General Hospital
- Residency, Massachusetts General Hospital Residency Program i
- Fellowship, Mass General Hospital
- Fellowship, Massachusetts General Hospital
- Fellowship, Massachusetts General Hospital, Fellowship in Pain
American Board Certifications
- Radiology - Neuroradiology, American Board of Radiology
- Diagnostic Radiology, American Board of Radiology
- Neuroradiology, American Board of Radiology
- Neuroradiology, American Board of Radiology
- Diagnostic Radilogy, American Board of Radiology
Accepted Insurance Plans
- Aetna Health Inc.
- AllWays Health (NHP) - ACD
- AllWays Health (NHP) - PBO
- Beech Street
- Blue Cross Blue Shield - Blue Care 65
- Blue Cross Blue Shield - Indemnity
- Blue Cross Blue Shield - Managed Care
- Blue Cross Blue Shield - Partners Plus
- BMC HealthNet Mass Health MCO/ACO
- Cigna (PAL #'s)
- Commonwealth Care Alliance
- Fallon Community HealthCare
- Great-West Healthcare (formally One Health Plan)
- Harvard Pilgrim Health Plan - PBO
- Health Care Value Management (HCVM)
- Humana/Choice Care PPO
- Maine Community Health Options (MCHO)
- MassHealth
- Medicare
- Medicare - ACD
- OSW - Connecticut
- OSW - Maine
- OSW - New Hampshire
- OSW - Rhode Island
- OSW - Vermont
- Private Health Care Systems (PHCS)
- Railroad Medicare
- Railroad Medicare - ACD
- Senior Whole Health
- TriCare
- Tufts Health Plan
- Unicare
- United Healthcare (non-HMO) - ACD
- United Healthcare (non-HMO) - PBO
- Well Sense Pediatrics
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
My laboratory studies neuroinflammation, combining basic science research with a clinical focus. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.
Publications
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View my most recent publications at PubMed
- Rodriguez E, Nilges M, Weissleder R, Chen JW. Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. J Am Chem Soc. 2010;132(1):168-77
- Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK. Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques. Circulation. 2009;120(7):592-9
- McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2009;45(2):360-9
- Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R. Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase. P Natl Acad Sci U S A. 2008;105 (47):18584-18589
- Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R. Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain. 2008;131(Pt 4):1123-33