About Mingming Ning, MD, MMSC

Dr. MingMing Ning is Associate Professor and Director of the Cardio-Neurology Clinic at MGH.  She is a board-certified vascular neurologist employing a wide range of innovations from clinical omics/mass spectrometry to digital technology with music for stroke patients. Her pioneering work in PFO has opened a new field to monitor brain-heart communication through blood.  

Dr Ning collaborates widely and has co-authored more than 150 publications, participated in more than 100 clinical trials, received multiple innovation awards from the American Heart Association, American Academy of Neurology, American Federation for Medical Research and Howard Hughes Medical Institute. She has been named among America’s Top Physicians and has helped many other academic centers set up multi-disciplinary care modeled on the MGH Cardio-Neurology Clinic. As Director of the Clinical Proteomics Research Center, her NIH sponsored research uses state of the art mass spectrometry technology to explore various neurological diseases and therapeutic interventions directly at bedside to individualize treatment for stroke related to the heart.  

In addition to patient care, research and teaching, Dr Ning has served on various boards and committees including: President of the American Federation for Medical Research following Dr Anthony Fauci; FASEB Board, MGH Structural Heart Disease/PFO, ECMO, and Stroke Prevention in Atrial Fibrillation, and Harvard Medical School MPCTI Admission Committees. She is co-founder of the Brain/Heart-Music/Art Initiative to improve brain and heart health in the young, healthy aging, and those with vascular risk and cognitively impairment. Dr. Ning also serves as associate editor and editorial board member for various journals including BMJ/JIM, on various NIH/NINDS scientific review panels, and as co-chair of the OMICs section of the NIH/NINDS Stroke Progress Review Group.  

Departments, Centers, & Programs:

Clinical Interests:



Mass General Vascular Center: Stroke Service
55 Fruit St.
Wang Ambulatory Care Center
7th Floor, Suite 720
Boston, MA 02114
Phone: 617-726-8459

Spaulding Rehabilitation Hospital
300 First Ave.
Charlestown , MA 02129
Phone: 617-952-5000

Medical Education

  • MD, Boston University School of Medicine
  • Residency, Brigham and Women's Hospital
  • Residency, Massachusetts General Hospital
  • Fellowship, Brigham and Women's Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Neurology, American Board of Psychiatry and Neurology

Accepted Insurance Plans

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Research Description

Sponsored by the National Institutes of Health (NINDS), the Clinical Proteomics Research Center (CPRC) explores the clinical applications of proteomic technology. The goals of the Clinical Proteomics Research Center are to explore neurovascular pathophysiology using a translational approach, to develop prognostic tools to guide clinical decision-making, and to discover new targets of therapeutic intervention at the bedside. Read more about CPRC research in the application of proteomic technology to clinical problem solving in neurovascular disease on our Research Project page.

Research Laboratory Website & Profile

MingMing Ning, MD, MMSc, Clinical Proteomics Research Center  


  • Selected publications:

    Michael D, Martin KC, Seger R, Ning MM, Baston R, Kandel ER. Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons. Proc Natl Acad Sci USA. 1998;95(4):1864-9.

    Greenberg SM, Eng JA, Ning MM, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke. 2004;35(6):1415-20.

    Ning M, Furie KL, Koroshetz WJ, Lee H, Barron M, Lederer M, Wang X, Zhu M, Sorensen AG, Lo EH, Kelly PJ. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. Neurology. 2006 May 23;66(10):1550-5. doi: 10.1212/01.wnl.0000216133.98416.b4. PMID: 16717217

    Ning M, Gonzalez RG. Stroke Expert Case. New England Journal of Medicine 2013;369:1736-174

    Deng W, Yin S, McMullin D, Inglessis-Azuaje I, Elmariah S, Hung J, Lo EH, Palacios IF, Buonanno FS, Ning M. Residual Shunt after Patent Foramen Ovale Closure and Long-Term Stroke Recurrence: A Prospective Cohort Study. Ann Intern Med. 2020;172(11):717-25

    Deng W, McMullin D, Inglessis-Azuaje I, Locascio JJ, Palacios IF, Buonanno FS, Lo EH, Ning M. Effect of Patent Foramen Ovale Closure after Stroke on Circulatory Biomarkers. Neurology. 2021;97(2):203-14.

    Deng W, Mansour M, Song B, Hou H, Liu K, Xu Y, McMullin D, Buonanno FS, Lo EH, Ning M. Fall Outcomes With Left Atrial Appendage Occlusion vs Direct Oral Anticoagulants for Atrial Fibrillation. J Am Coll Cardiol. 2023 Jul 25;82(4):379-381. doi: 10.1016/j.jacc.2023.05.032. PMID: 37468192.

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