Allen Steere, MD
Allen Steere, MD
Professor of Medicine, Harvard Medical School
Director of Translational Research in Rheumatology, Massachusetts General Hospital
Departments, Centers, & Programs:
55 Fruit Street
Boston, MA 02114-2696
- MD, Columbia University College of Physicians and Surgeons
- Residency, St. Luke's Hospital
- Fellowship, Yale University School of Medicine
American Board Certifications
- Internal Medicine, American Board of Internal Medicine
- Rheumatology, American Board of Internal Medicine
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The Steere lab specializes in the identification of novel antigens, including those from infectious agents or self-proteins, the elucidation of immune responses to these antigens, and the determination of microbial and host genetic factors that underlie adverse clinical outcomes.
This work requires a combination of discovery-based genomic, transcriptomic and proteomic approaches as well as functional studies using cells and affected tissues.
These include determinations of T cell and antibody phenotypes and function and deep characterization of implicated immune cells using genomics and transcriptomics.
This translational research, which is based on the study of human patients, has implications for pathogenesis, diagnosis and treatment of patients with these diseases.
Dr. Steere has authored more than 300 articles on Lyme disease and has recently published several articles on rheumatoid arthritis. His complete list of publications can be accessed through the PubMed Url link
Several recent examples are listed here.
1. Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JWR, Li X, Mead PS. Lyme borreliosis. Nature Rev Dis Primers doi:10.1038/nrdp.2016.90. PMID:2796670.
2. Branda J, Strle K, Nigrocic LE, Lantos PM, Lepore TJ, Damle NS, Ferraro MJ, Steere AC. Evaluation of modified 2-tiered serodiagnostic testing algorithms for early Lyme disease. Clin Infect Dis 2017;64:1074-80 PMCID:PMC5399943.
3. Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC. MicroRNA expression shows inflammatory dysregulation and tumor-like proliferative responses in joints of patients with post-infectious Lyme arthritis. Arthritis Rheumatol 2017;69:1100-1110. PMCID:PMC5406251.
4. Pianta A. Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Two rheumatoid arthritis-specific autoantigens correlate with autoimmune responses in joints. J Clin Invest 2017;127:2946-2956.
5. Post-treatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses. J Clin Invest 2020;130:130:2148-2151.