How the EWS-FLI1 fusion protein promotes tumor formation in Ewing Sarcoma is not fully understood and is the focus of new research from the lab of Miguel N. Rivera, MD.
Departments, Centers, & Programs:
55 Fruit Street
Boston, MA 02114-2696
- MD, Harvard Medical School
- Residency, Brigham and Women's Hospital
American Board Certifications
- Anatomic Pathology, American Board of Pathology
- Molecular Genetic Pathology, American Board of Medical Genetics
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Our laboratory uses genomic technologies to identify and characterize pathways implicated in pediatric solid tumors and sarcomas. Read more about the Rivera Lab.
Rivera MN, Kim WJ, Wells J, Stone A, Burger A, Coffman EJ, Zhang J, Haber DA (2009). The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. Proceedings of the National Academy of Sciences U S A, 106(20):8338-43.
Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA (2007). An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science, 315: 642-5.
Rivera MN, Haber DA (2005) Wilms tumor: connecting tumorigenesis and organ development in the kidney. Nature Reviews Cancer, 5(9):699-712.
Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C (2004). Detection of large-scale variation in the human genome. Nature Genetics, 36(9):949-51.
- mgh research scholar
Miguel Rivera, MD, is investigating how abnormalities in gene regulation in pediatric brain and bone cancers (medulloblastoma and Ewing sarcoma respectively) drive the growth of these tumors.
- May | 17 | 2019
The 2019 Scientific Advisory Committee (SAC) meeting reflected a shift in focus from the progress of research at the MGH to the challenges facing members of the hospital’s research faculty.