About John Higgins, MD

John Higgins, MD, is a Pathologist at Massachusetts General Hospital and a Professor of Systems Biology at Harvard Medical School.  His clinical work focuses on the diagnostic interpretation of clinical hematology and immunology studies.  His research program studies the dynamics of human pathophysiologic processes by developing mechanistic mathematical models of complex human disease phenotypes and is located in the MGH Center for Systems Biology.  

Departments, Centers, & Programs:

Clinical Interests:



Mass General Pathology
55 Fruit St.
Boston, MA 02114
Phone: 617-643-0800

Medical Education

  • MD, Harvard Medical School (Massachusetts)
  • Residency, Brigham and Women's Hospital
  • Fellowship, Brigham and Women's Hospital

American Board Certifications

  • Clinical Pathology, American Board of Pathology

Accepted Insurance Plans

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Dr. Higgins studies the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.

See details at the Higgins Lab.


  • 1. Foy BH, Carlson JCT, Reinertsen E, Padros I Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection. JAMA Network Open. 2020 (PMID: 32965501)

    2. Di Caprio G*, Schonbrun E*, Gon?alves BP, Valdez JM, Wood DK, Higgins JM High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension.PNAS 2019 (PMID 31767751)

    3. Chaudhury A, Miller GD, Eichner D, Higgins JM Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss. eLife. 2019 (PMID: 31845889).

    4. Malka R, Nathan DM, Higgins JM Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring Science Translational Medicine 2016 (PMID: 277080630.

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