Research Roundup
Research at the Mass General is interwoven throughout more than 30 departments, centers and units, and is conducted with the support and guidance of the Mass General Research Institute.
About John Higgins, MD
John Higgins, MD, is a Pathologist at Massachusetts General Hospital and a Professor of Systems Biology at Harvard Medical School. His clinical work focuses on the diagnostic interpretation of clinical hematology and immunology studies. His research program studies the dynamics of human pathophysiologic processes by developing mechanistic mathematical models of complex human disease phenotypes and is located in the MGH Center for Systems Biology.
Clinical Interests:
- Hemoglobinopathies
- Laboratory Hematology
- Laboratory Immunology
- Thrombosis and hemostasis
Treats:
- Adult & Pediatrics
Locations
Mass General Pathology
55 Fruit St.
Boston, MA 02114
Phone: 617-643-0800
Medical Education
- MD, Harvard Medical School
- Residency, Brigham and Women's Hospital
- Fellowship, Brigham and Women's Hospital
American Board Certifications
- Clinical Pathology, American Board of Pathology
Accepted Insurance Plans
- Aetna Health Inc.
- Beech Street
- Blue Cross Blue Shield - Blue Care 65
- Blue Cross Blue Shield - Indemnity
- Blue Cross Blue Shield - Managed Care
- Blue Cross Blue Shield - Partners Plus
- BMC HealthNet Mass Health MCO/ACO
- Centene/Celticare
- Cigna (PAL #'s)
- Commonwealth Care Alliance
- Fallon Community HealthCare
- Great-West Healthcare (formally One Health Plan)
- Harvard Pilgrim Health Plan - ACD
- Harvard Pilgrim Health Plan - PBO
- Health Care Value Management (HCVM)
- Humana/Choice Care PPO
- Maine Community Health Options (MCHO)
- Mass General Brigham Health Plan - ACD
- Mass General Brigham Health Plan - PBO
- MassHealth
- Medicare
- Medicare - ACD
- Medicare ACO - ACD
- Medicare ACO - PBO
- OSW - Connecticut
- OSW - Maine
- OSW - New Hampshire
- OSW - Rhode Island
- OSW - Vermont
- Private Health Care Systems (PHCS)
- Railroad Medicare
- Railroad Medicare - ACD
- Senior Whole Health
- TriCare
- Tufts Health Plan
- Unicare
- United Healthcare (non-HMO) - ACD
- United Healthcare (non-HMO) - PBO
- Well Sense Pediatrics
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Dr. Higgins studies the dynamics of human pathophysiologic processes by developing mathematical descriptions of complex human disease phenotypes and how they change over time.
See details at the Higgins Lab.
Publications
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1. Foy BH, Carlson JCT, Reinertsen E, Padros I Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection. JAMA Network Open. 2020 (PMID: 32965501)
2. Di Caprio G*, Schonbrun E*, Gon?alves BP, Valdez JM, Wood DK, Higgins JM High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension.PNAS 2019 (PMID 31767751)
3. Chaudhury A, Miller GD, Eichner D, Higgins JM Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss. eLife. 2019 (PMID: 31845889).
4. Malka R, Nathan DM, Higgins JM Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring Science Translational Medicine 2016 (PMID: 277080630.