Departments, Centers, & Programs:
Infectious Disease Associates
55 Fruit Street
Boston, MA 02114-2696
- MD, PhD, Baylor College of Medicine
- Residency, Massachusetts General Hospital
- Fellowship, Massachusetts General Hospital
American Board Certifications
- Internal Medicine, American Board of Internal Medicine
- Infectious Disease, American Board of Internal Medicine
Accepted Insurance Plans
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We wish to understand the rules that govern host defenses against invasive fungal infections and the molecular basis of recognition of pathogenic yeast by immune cells. To this end, my lab has investigated phagosome maturation within antigen presenting cells and how this process influences antigen processing and presentation. To conduct these studies, we employ advanced microscopy to visualize dynamic subcellular changes upon phagocytosis by macrophages and dendritic cells. We have developed novel tools to dissect this immune response including the development of synthetic fungal like particles, which display highly-purified carbohydrates of fungal origin that trigger inflammatory responses in innate immune cells. My collection of work has demonstrated that specific recruitment of mammalian proteins to phagosomes depends on its content and potently modulates the ensuing immune response.