About Jay Vyas, MD, PhD

As an immunologist and infectious disease  specialist, I focus on basic investigations of  host-pathogen interactions.  I have a long-standing interest in immune response to infections. My  laboratory focuses on the innate immune responses to clinically relevant fungal  pathogens. We employ both cell biological and biochemical tools to understand  the molecular mechanisms that govern host immunity to these microorganisms. Using  mouse models with defined defects in innate immunity, we have described key  mechanisms that orchestrate this immune response to fungal infections.

I also serve as the tenth Program Director of the  Massachusetts General Hospital Department of Medicine Residency Program. I  currently supervise 168 interns and residents. As an NIH-funded investigator  with interests in basic science, I provide a unique perspective to the medical  housestaff. Outstanding clinical care is fueled by basic discovery and our  greatest opportunities to improve patient care comes from high-quality  research.

Departments, Centers, & Programs:



Mass General Infectious Diseases
55 Fruit St.
Boston, MA 02114
Phone: 617-726-3906

Medical Education

  • MD, Baylor College Of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Brigham and Women's Hospital
  • Fellowship, Massachusetts General Hospital

American Board Certifications

  • Infectious Disease, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine

Accepted Insurance Plans

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We wish to understand the rules that govern host defenses against invasive fungal infections and the molecular basis of recognition of pathogenic yeast by immune cells. To this end, my lab has investigated phagosome maturation within antigen presenting cells and how this process influences antigen processing and presentation. To conduct these studies, we employ advanced microscopy to visualize dynamic subcellular changes upon phagocytosis by macrophages and dendritic cells. We have developed novel tools to dissect this immune response including the development of synthetic fungal like particles, which display highly-purified carbohydrates of fungal origin that trigger inflammatory responses in innate immune cells. My collection of work has demonstrated that specific recruitment of mammalian proteins to phagosomes depends on its content and potently modulates the ensuing immune response.


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