A Massachusetts General Hospital Neurosurgeon Works to Develop the First Blood-Based Test for Patients with Brain Tumors.
Departments, Centers, & Programs:
Pappas Center for Neuro Oncology
55 Fruit Street
Boston, MA 02114
- MSC, Harvard T. H. Chan School of Public Health
- MD, Yale University School of Medicine
- Residency, Massachusetts General Hospital
- Fellowship, New England Baptist Hospital
American Board Certifications
- Neurological Surgery, American Board of Neurological Surgery
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Circulating Tumor Cells in Brain Tumor Patients and Blood Based Biomarkers for Brain Tumor Patients
Dr. Brian Nahed's research recently identified the first evidence of tumor cells in the blood of patients with brain tumors - a landmark finding which changes our understanding of brain tumors and the blood. Dr. Nahed and his colleagues developed the first device which they used to identify, capture, and analyze circulating tumor cells in the blood of patients with brain cancer. Through a collaboration between bioengineers, molecular biologists and clinicians, a circulating tumor cell capture device was developed to capture and detect tumor cells from patients with cancer. Under the mentorship of Drs. Daniel Haber, Shyamala Maheswaran, and Mehmet Toner, they aim to harness this technology to genetically characterize tumor cells without needing an invasive biopsy, and determine responsiveness to targeted cancer drugs. It also offers the opportunity to study cancer stem cells or metastatic precursors, thought to be at the origin of cancer spread via the bloodstream, to define their molecular vulnerabilities and help design new therapies to prevent cancer metastasis. Dr. Nahed has joined Dr. Shannon Stott to develop the first clinical tool to identify and monitor brain tumor patients using a blood test - expanding on their individual work on circulating tumor cells and exosomes.
Dr. Nahed's research was recently published in Cancer Discovery and he is active enrolling patients in his translational clinical research study. More information about his research lab can found here. Please contact him for any questions regarding his research or to inquire on how to enroll.
Dr. Brian Nahed has authored 128 publications in peer-reviewed journals and several book chapters and blogs.
Please refer to PubMed for a complete list of the publications.
Dr. Brian Nahed has developed the first blood based test to diagnose brain tumors from patient's blood. Together with Dr. Shannon Stott, their research lab is focused on developing a liquid biopsy for patients with brain tumors . More information about the research can be found at the Brian Nahed Brain Tumor Research Lab Website or at www.briannahed.com.
- Nov | 1 | 2018
In this new study, Shannon Stott, PhD & Brian Nahed, MD, MSc describe a new technique that uses microfluidics and engineered nanosurfaces to capture EVs released from glioblastoma multiforme.
- Nov | 1 | 2018
In this new study, Shannon Stott, PhD and Brian Nahed, MD, MSc describe a new technique that uses microfluidics and engineered nanosurfaces to capture EVs released from glioblastoma multiforme.